Ultrasmall Coordination Polymers for Alleviating ROS-Mediated Inflammatory and Realizing Neuroprotection against Parkinson's Disease
作者机构：Key Laboratory of Modern Preparation of Traditional Chinese MedicineMinistry of EducationJiangxi University of Chinese MedicineNanchang 330004China Institute of Molecular Medicine(IMM)Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200240China Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhou 510405China School of Cellular and Molecular MedicineUniversity of BristolBristol BS81THUK Institute of Functional Nano e Soft Materials Laboratory(FUNSOM)Soochow UniversitySuzhouJiangsu 215123China
出 版 物：《Research》 (研究（英文）)
年 卷 期：2022年第2022卷第4期
页 面：531-546页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100204[医学-神经病学] 10[医学]
基 金：We are grateful for the financial support from the National Natural Science Foundation of China(22107065) the Guangdong Basic and Applied Basic Research Foundation(2019B1515120043) the Open Project of Key Laboratory of Modern Preparation of Traditional Chinese Medicine,Ministry of Education,Jiangxi University of Chinese Medicine(zdsys-202101).
主 题：inflammation pathogenesis clinical
摘 要：Parkinson s disease(PD)is the second most common neurodegenerative disease globally,and there is currently no effective treatment for this condition.Excessive accumulation of reactive oxygen species(ROs)and neuroinflammation are major contributors to PD pathogenesis.Herein,ultrasmall nanoscale coordination polymers(NCPs)coordinated by ferric ions and natural product curcumin(Cur)were exploited,showing efficient neuroprotection by scavenging excessive radicals and suppressing neuroinflammation.In a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine(MPTP)-induced mouse PD model,such ultrasmall Fe-Cur NCPs with prolonged blood circulation and BBB traversing capability could effectively alleviate oxidative stress,mitochondrial dysfunction,and inflammatory condition in the midbrain and striatum to reduce PD symptoms.Thus,this study puts forth a unique type of therapeutics-based NCPs that could be used for safe and efficient treatment of PD with potential in clinical translation.
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