Molecular mechanism of peritoneal dissemination in gastric cancer
Molecular mechanism of peritoneal dissemination in gastric cancer作者机构:Department of SurgeryKyushu University Beppu HospitalBeppu 874-0838Japan Department of Surgery and ScienceKyushu University HospitalFukuoka 812-8582Japan Division of Biomarker DiscoveryExploratory Oncology Research&Clinical Trial CenterNational Cancer CenterKashiwa 277-8577Japan
出 版 物:《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗(英文版))
年 卷 期:2018年第4卷第1期
页 面:451-458页
学科分类:1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题:Gastric cancer peritoneal dissemination molecular mechanism
摘 要:Peritoneal dissemination(PD)is the most common cause of metastasis in gastric cancer(GC).Because there are no standard treatments for PD,it is associated with a poor prognosis.Although clinicians have performed intraperitoneal chemotherapy for GC with PD,the outcome remains unsatisfactory.Therefore,the development of novel treatments and diagnostic tools for PD is expected to improve the prognosis of GC patients with PD.Notably,it is essential to elucidate the molecular mechanisms involved in the development of PD in GC.In this review,the molecular mechanisms of PD(three steps:detachment from the primary tumor,adaptation to the microenvironment of the peritoneal cavity,and attachment to peritoneal mesothelial cells)and new topics in GC are highlighted.