Usefulness of fecal lactoferrin and hemoglobin in diagnosis of colorectal diseases

作     者：Ichiro Hirata Masahiro Hoshimoto Osamu Saito Masanobu Kayazawa Takashi Nishikawa Mitsuyuki Murano Ken Toshina Fang-Yu Wang Ryoichi Matsuse 

作者机构：Department of Gastroenterology Fujita Health University Japan SecondDepartment of Internal Medicine Osaka Medical College Japan Department of GastroenterologyJinling Hospital Nanjing University School of Medicine China Kyoto Medical Science Laboratory Japan 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2007年第13卷第10期

页      面：1569-1574页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：Feces Lactoferrin Hemoglobin Diagnosis Colorectal disease 

摘      要：AIM:To evaluate prospectively usefulness of fecal lactoferrin(Lf)and fecal hemoglobin(Hb)in the diagnosis of colorectal ***:Fecal Lf and Hb were measured using ELISA in 872 patients before they underwent colorectal ***:Lf was positive in 18(50%)of 36 patients with colorectal cancer,25(15.9%)of 157 with colorectal polyps,29(46.8%)of 62 with ulcerative colitis,and 25(62.5%)of 40(62.5%)with Crohn s *** Hb-positive rates were 50%,12.1%,41.9% and 32.5%,*** the 318 patients free of abnormalities by colorectal endoscopy,Lf was positive in 29(9.1%)and Hb was positive in 15(4.7%).Among patients with Crohn s disease,the Lf-positive rate was significantly higher than the Hb-positive *** either high Lf or Hb levels were considered positive,the positive rates rose to 61.1%,51.6%,and 67.5% in the colorectal cancer group,ulcerative colitis group,and Crohn s disease group,*** both high Lf and Hb levels were rated positive,the positive predictive values(PPV)were 21% for colorectal cancer,33% for ulcerative colitis,and 17% for Crohn s disease,and PPV of high Hb level alone was 18%,25% and 13%,***:Fecal Lf and Hb were found useful in the detection of colorectal diseases,and the combination of the two measurements appears to increase the sensitivity and efficacy of diagnosis.