Hedgehog signaling pathway and ovarian cancer

作     者：Qi Chen Guolan Gao Shiwen Luo 

作者机构：Department of Obstetrics and Gynecology The Second Affiliated Hospital of Nanchang University Department of Obstetrics and Gynecology General Hospital of Beijing Aeronautics Center for Experimental Medicine The First Affiliated Hospital of Nanchang University 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2013年第25卷第3期

页      面：346-353页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by Grants from the National Natural Science Foundation of China (No. 31171359) the Ministry of Science and Technology of China (No.2010CB535001) 

主　　题：Hedgehog signaling ovarian cancer targeted therapy 

摘      要：Epithelial ovarian carcinoma （EOC） is the most common form of ovarian malignancies and the most lethal gynecologic malignancy in the United States. To date, in spite of treatment to it with the extensive surgical debulking and chemotherapy, the prognosis of EOC remains dismal. Recently, it has become increasingly clear that in many instances, the signaling and molecular players that control development are the same, and when inappropriately regulated, drive tumorigenesis and cancer development. Here, we discuss the possible involvement of Hedgehog （Hh） pathway in the cellular regulation and development of cancer in the ovaries. Using the in vitro and in vivo assays developed has facilitated the dissection of the mechanisms behind Hh-driven ovarian cancers formation and growth. Based on recent studies, we propose that the inhibition of Hh signaling may interfere with spheroid-like structures in ovarian cancers. The components of the Hh signaling may provide novel drug targets, which could be explored as crucial combinatorial strategies for the treatment of ovarian cancers.