S100B protein in the gut:The evidence for enteroglial-sustained intestinal inflammation

作     者：Carla Cirillo Giovanni Sarnelli Giuseppe Esposito Fabio Turco Luca Steardo Rosario Cuomo 

作者机构：Department of Clinical and Experimental MedicineUniversity of Naples "Federico Ⅱ" Department of Human Physiology and PharmacologyUniversity of Rome "La Sapienza" 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2011年第17卷第10期

页      面：1261-1266页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Supported by research funds from the Italian Ministry of University and Research (COFIN Projects No. 2004062155 to GS and RC) 

主　　题：Enteric glial cells Nitric oxide Intestinaldiseases 

摘      要：Glial cells in the gut represent the morphological and functional equivalent of astrocytes and microglia in the central nervous system （CNS）. In recent years, the role of enteric glial cells （EGCs） has extended from that of simple nutritive support for enteric neurons to that of being pivotal participants in the regulation of inflammatory events in the gut. Similar to the CNS astrocytes, the EGCs physiologically express the SIOOB protein that exerts either trophic or toxic effects depending on its concentration in the extracellular milieu. In the CNS, SIOOB overexpression is responsible for the initiation of a gliotic reaction by the release of pro-inflammatory mediators, which may have a deleterious effect on neighboring cells. SlOOB-mediated pro-inflammatory effects are not limited to the brain： SIOOB overexpression is associated with the onset and maintenance of inflammation in the human gut too. In this review we describe the major features of EGCs and SIOOB protein occurring in intestinal inflammation deriving from such.