Construction of comprehensive gene network for human mitochondria

作     者：LI Jie GAO Song WANG Jin ZHANG ChenYu 

作者机构：State Key Laboratory of Pharmaceutical Biotechnology School of Life Science Nanjing University Nanjing 210093 China 

出 版 物：《Chinese Science Bulletin》 (Chin. Sci. Bull.)

年 卷 期：2010年第55卷第22期

页      面：2366-2372页

核心收录：

学科分类：0710[理学-生物学] 12[管理学] 1201[管理学-管理科学与工程(可授管理学、工学学位)] 07[理学] 08[工学] 071009[理学-细胞生物学] 09[农学] 0901[农学-作物学] 090102[农学-作物遗传育种] 081201[工学-计算机系统结构] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：supported by the National Basic Research Program of China (2003CB715905) 

主　　题：网络建设 基因网络 线粒体 人类 细胞凋亡 新陈代谢 拓扑分析 细胞生长 

摘      要：By combining the knowledge from KEGG database and literatures, we construct a comprehensive gene network for human mitochondria. The network comprises 2442 genes of 9 functional categories, including metabolism, development, immune, and apoptosis, etc. Topological analysis reveals that the network is scale free. The hubs of high degrees are mostly the genes of apoptosis. Three big modules are found in the network, which represent development and cell growth, metabolism, immune and apoptosis respectively, suggesting the multiplicity of functions and the complexity of gene regulation in mitochondria.