Effects of the Huangkui capsule(黄葵胶囊)on chronic kidney disease:a systematic review and Meta-analysis

作     者：LI Wei XIA Ping SUN Wei ZHAO Jing LIU Qiong GENG Lianyi ZHOU Yao GAO Kun LI Wei;XIA Ping;SUN Wei;ZHAO Jing;LIU Qiong;GENG Lianyi;ZHOU Yao;GAO Kun

作者机构：Division of NephrologyJiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China the First Affiliated Hospital of Soochow UniversitySuzhou 215000China Laboratory of Clinical and Experimental PathologyDepartment of PathophysiologyXuzhou Medical UniversityXuzhou 221009China 

出 版 物：《Journal of Traditional Chinese Medicine》 (中医杂志（英文版）)

年 卷 期：2023年第43卷第1期

页      面：6-13页

核心收录：

学科分类：1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床] 

基　　金：Supported by the National Natural Science Foundation of China:Study on the mechanism of Yishen Qingli Huoxue formula regulating autophagy in kidney injury caused by metabolic disorder(No.81774245) the Protective Effect of Abelmoschus Manihot via Regulating NLRP3 Inflammasome—Pyroptosis on Renal Tubule Cells(No.81873259) the Mechanism of Tanshinone IIA Regulates Txnip/TRX-NLRP3 Inflammasome to Inhibit Pyroptosis and Protect Glomerular Endothelial Cells(No.82004107) Jiangsu Province Hospital of Chinese Medicine Hospital-level Project,Molecular Mechanism of Abelmoschus Manihot Regulating Fatty Acid Oxidation in Renal Tubule Cells and Antagonizing Renal Fibrosis(No.Y20026)。 

主　　题：renal insufficiency,chronic Huangkui capsule blood urea nitrogen glomerular filtration rate systematic review Meta-analysis 

摘      要：OBJECTIVE:To collect data and investigate the effects of Huangkui capsule(黄葵胶囊,HKC)on chronic kidney disease(CKD).METHODS:PubM ed,Embase,Cochrane Library,and three Chinese databases(China National Knowledge Infrastructure,Wanfang,and China Science and Technology Journal Database)were searched for articles published until October 2020.Randomized controlled trials(RCTs)of HKCs used for treating CKD were reviewed.Data were organized and analyzed using RevMan 5.3 software.RESULTS:HKC significantly lowered the blood urea nitrogen(BUN)level[mean difference(MD)=-2.26;95%confidence interval(CI),-2.91 to-1.61],serum creatinine level(MD=-17.45;95%CI,-22.29 to-12.60),and 24-h urine protein content(MD=-0.73;95%CI,-1.00 to-0.46)and improved the glomerular filtration rate(GFR)(MD=10.69;95%CI,5.57 to 15.81)and serum albumin level(MD=2.20;95%CI,0.49 to 3.90).CONCLUSIONS:Our findings show that HKC could lower the BUN level,serum creatinine level,and 24-h urine protein content.HKC also improved GFR and serum albumin levels.However,high-quality RCTs in other countries with larger sample sizes are warranted to confirm these findings.