Natural products:potential therapeutic agents for atherosclerosis
作者机构：State Key Laboratory of Natural Medicines and Jiangsu Key Laboratory of Bioactive Natural Product ResearchSchool of Traditional Chinese PharmacyChina Pharmaceutical UniversityNanjing 210009China Institute of Veterinary MedicineJiangsu Academy of Agricultural SciencesNanjing 210014China
出 版 物：《Chinese Journal of Natural Medicines》 (中国天然药物（英文版）)
年 卷 期：2022年第20卷第11期
页 面：830-845页
核心收录：
学科分类：1007[医学-药学(可授医学、理学学位)] 1006[医学-中西医结合] 1002[医学-临床医学] 10[医学] 100602[医学-中西医结合临床]
基 金：supported by the National Natural Science Foundation of China(Nos.81872986 and 31900159) the Drug Innovation Major Project(Nos.2018ZX09711-001-007 and 2018ZX09735002-003).
主 题：Atherosclerosis Cardiovascular diseases Pathogenesis Target Natural products
摘 要：Atherosclerosis(AS)is an invisible killer among cardiovascular diseases(CVD),which has seriously threatened the life of quality.The complex pathogenesis of AS involves multiple interrelated events and cell types,such as macrophages,endothelial cells,vascular smooth muscle cells and immune cells.Currently,the efficacy of recommended statin treatment is not satisfactory.Natural products(NPs)have attracted increasing attention with regard to their broad structural diversity and biodiversity,which makes them a promising library in the demand for lead compounds with cardiovascular protective bio-activity.NPs can preclude the development of AS by regulating lipid metabolism,ameliorating inflammation,stabilizing plaques,and remodeling the gut microbiota,which lays a foundation for the application of NPs in clinical therapeutics.
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