THE BIOLOGICAL FUNCTION OF RABBIT BLASTOCYST PEPTIDES (RBPs)

作     者：曹永清 陈幼珍 郑明 张致一 

作者机构：Laboratory of Reproductive Biology and Department of Endocrinology Institute of Zoology Academia Sinica Beijing 100080 PRC 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：1991年第34卷第1期

页      面：64-70页

核心收录：

学科分类：0810[工学-信息与通信工程] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 07[理学] 0708[理学-地球物理学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0703[理学-化学] 0704[理学-天文学] 0812[工学-计算机科学与技术（可授工学、理学学位）] 

基　　金：Project supported in part by a grant-in-aid from the Rockefeller Foundation  New York 

主　　题：implantation blastocystic peptide lymphocyte transformation prostaglandin F_(2α) 

摘      要：The inhibitory effect of rabbit blastocystic peptides (RBPs) on lymphocyte transfor- mation was studied by the method of measuring the incorporation of ~3H- thymidine into DNA. The results indicated that RBPs inhibited PHA-stimulated rat and human lympho- cyte transformation in vitro. In the concentration ranging from 40 to 200 μg/2.5 ml, the inhibition was dose-dependent. No obvious inhibitory action was found with hCG (16- 128 IU/2.5 ml), progesterone (250 ng- 1 μg/2.5 ml) and pregnant rabbit serum. It was further demonstrated that RBPs at a higher dosage (200 μg/ml) was inhibitory to PGF_(2α) secretion. On the other hand, the ~3H- leucine incorporation of rabbit endometrium was enhanced by these peptides, and this action could be blocked by the addition of actidine.