Activatable molecular fluorescence probes for the imaging and detection of ischemic stroke

作     者：Mengdie Wang Yan Zhang 

作者机构：Department of NeurologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022HubeiChina National Engineering Research Centre for NanomedicineCollege of Life Science and TechnologyHuazhong University of Science and TechnologyWuhan 430074HubeiChina 

出 版 物：《Brain Science Advances》 (神经科学（英文）)

年 卷 期：2023年第9卷第1期

页      面：35-42页

学科分类：1002[医学-临床医学] 100204[医学-神经病学] 10[医学] 

基　　金：supported by the National Key Research and Development Program of China(Grant No.2021YFA1201203) 

主　　题：molecular imaging protease metal ion ROS fluorescence probe ischemic stroke detection 

摘      要：The real-time, noninvasive, nonionizing, high spatiotemporal resolution, and flexibility characteristics of molecular fluorescence imaging provide a uniquely powerful approach to imaging and monitoring the physiology and pathophysiology of ischemic stroke. Currently, various fluorescence probes have been synthesized with the aim of improving quantitative and quantitative studies of the pathologic processes of ischemic stroke in living animals. In this review, we present an overview of current activatable fluorescence probes for the imaging and diagnosis of ischemic stroke in animal models. We categorize the probes based on their activatable signals from the biomarkers associated with ischemic stroke, and we present representative examples of their functional mechanisms. Finally, we briefly discuss future perspectives in this field.