Clinical application of ¹³C-Hiolein breath test in assessing pancreatic exocrine insufficiency

作     者：DaYu Sun YiBing Jiang Lan Rong ShaoJing Jin WengZhang Xie 

作者机构：Department of Gastroenterology Huashan Hospital Fudan University Shanghai 200040 China. sdy385@*** 

出 版 物：《Hepatobiliary & Pancreatic Diseases International》 (国际肝胆胰疾病杂志（英文版）)

年 卷 期：2003年第2卷第3期

页      面：449-452页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：pancreatitis pancreatic exocrine breath test Hiolein 

摘      要：OBJECTIVE: To examine the feasibility and significance of 13C-Hiolein breath test in evaluating chronicpancreatitis-related exocrine insufficiency and efficacy of enzyme ***: The 13C-Hiolein breath test was used in 8 healthy volunteers （group 1）, 8 chronicpancreatitis （CP） patients without steatorrhea （group 2）, and 8 CP patients with steatorrhea （group 3）.To evaluate the function of pancreatic exocrine, 13CO2 was determined following 13C-Hiolein diet. The13C-Hiolein test was repeated in group 3 after enzyme supplement ***: Administration of 13C-Hiolein diet resulted in significantly higher cumulative percent dose of13C recovery per 6 h （cPDR/6 h） and maximal PDR (PDRpeak) in the healthy controls （group 1） thanthe CP patients with steatorrhea （group 3） （11.22%±1.22% and 6.11%±0.59% vs. 2.87%±0.73%and 1.53%±0.36%, respectively, both Ppeak （9.03%±0.84% and 2.33%±0.47%, both Ppeak in the CP patients without steatorrhea （group 2） were similar to those inthe healthy controls （group 1, both P0.05）.CONCLUSION: The results of 13C-Hiolein breath test well reflect fat metabolism status in CP patients,and the test can be used to monitor the efficacy of pancreatic enzymes therapy.