A network pharmacology approach to explore the mechanism of action of Yiqi Fumai lyophilized injection in the treatment of novel coronavirus disease
作者机构：School of Pharmaceutical Science and TechnologyTianjin UniversityTianjin 300072China School of International EducationTianjin UniversityTianjin 300072China Clinical School of Changsha Health Vocational CollegeChangsha 410100China Tasly Pride Pharmaceutical Company LimitedTianjin 300410China Tianjin Pharmaceutical Research InstituteTianjin 300072China
出 版 物：《Traditional Medicine Research》 (TMR传统医学研究)
年 卷 期：2023年第8卷第3期
页 面：1-9页
学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 10[医学]
基 金：National Natural Science Foundation of China(No.81673535) the Science and Technology Project of Tianjin(No.18ZXXYSY00080)
主 题：network pharmacology novel corona virus traditional Chinese medicine natural compounds inflammation
摘 要：Background:Shengmai decoction,which has been included in the diagnosis and treatment of coronavirus disease 2019(COVID-19),is effective in the early treatment of patients with severe *** Fumai lyophilized injection(YQFM)is a modern Chinese medicine preparation of the Shengmai *** mechanism of its intervention at the molecular level in the severe stage of COVID-19 remains ***,it is necessary to investigate the mechanism of YQFM in the treatment of patients with severe ***:The corresponding target genes of the main active ingredients in YQFM and COVID-19 were obtained by using multiple databases and literature retrieval.A protein-protein interaction network was constructed,and enrichment analysis of the target was performed using Cytoscape ***,the docking of all the identified compounds with angiotensin-converting enzyme II was confirmed by applying molecular docking ***:YQFM has anti-inflammatory effects on RAW267.4 *** main active compounds of YQFM are all effective anti-inflammatory agents,and these active compounds also show beneficial physiological functions,such as anti-oxidation,anti-bacterial,and anticancer *** Ontology analysis showed enrichment in the following pathways:lipopolysaccharides,interleukins,NF-kappa B,interleukin-2 and others,revealing that YQFM may play a role in the treatment of patients with severe COVID-19 through these ***:YQFM has multicomponent and multitarget characteristics,and it could reduce lung injury by inhibiting inflammatory reactions,promoting antiviral activities,and regulating immunity,among other functions,to treat patients with severe COVID-19.
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