Host cell cycle checkpoint as antiviral target for SARS-CoV-2 revealed by integrative transcriptome and proteome analyses
作者机构：Department of Infectious DiseasesInfectious diseases and Pathogen Biology CenterKey Laboratory of Organ Regeneration and Transplantation of the Ministry of EducationThe First Hospital of Jilin UniversityState Key Laboratory of Zoonotic DiseasesChangchun130021China Research Unit of Key Technologies for Prevention and Control of Virus ZoonosesChinese Academy of Medical SciencesChangchun Veterinary Research InstituteChinese Academy of Agricultural SciencesChangchun130117China College of Basic Medical ScienceJilin UniversityChangchun130021China
出 版 物：《Signal Transduction and Targeted Therapy》 (信号转导与靶向治疗（英文）)
年 卷 期：2023年第8卷第2期
页 面：341-343页
核心收录：
学科分类：0710[理学-生物学] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：This work was supported by grant from the National Natural Science Foundation of China(81972873,82002165,81871699,and 82072330) the Biosafety Research Special Plan of the Logistics Support Department of the Military Commission(923070201202) the young and middle-aged science and technology innovation leaders and teams of the Jilin Provincial Department of Science and Technology(20200301001RQ) China Ministry of Science and Technology Key Research and Development Program(2022YFF1203204) Jilin Province Pathogen and Infection Informatics International Joint Research Center(20210504004GH) the Pearl River Talent Plan in Guangdong Province of China(2019CX01N111) the Scientific and Technological Research Projects of Guangzhou,China(202103000008) the Medical Innovation Team Project of Jilin University(2022JBGS02)
主 题：acute respiratory cycle
摘 要：Dear Editor,Severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),the causative agent of the COVID-19 pandemic,has posed severe threats to global public health,highlighting an urgent need to understand its pathogenesis and to develop antiviral *** DNA and RNA viruses can modulate cell cycle progression to maximize their replication.1 However,the effects of SARS-CoV-2 on cell cycle progression remains largely unknown.
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