肺炎衣原体感染可预测继发性特异性疾病发病风险降低

作     者：Normann E. Gnarpe J. Gnarpe H. Wettergren B. 李开 

作者机构：Department of Women 's and Children's Health Uppsala University Children's Hospital SE-751 85 Uppsala Sweden 

出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)

年 卷 期：2005年第1卷第10期

页      面：30-30页

学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学] 

主　　题：肺炎衣原体感染 发病风险 呼吸道感染 特异性 远期影响 拭子 间隔时间 特异反应 问卷调查 风险因子 

摘      要：Aim: To investigate long-term effects on children previously infected with Ch lamydia pneumoniae. Methods: A followup questionnaire was sent to all participan ts from a former population-based study in order to investigate health status d uring the 4 y that had elapsed between the two studies. In the original study, t he prevalence of C. pneumoniae infection was 23%as determined by PCR analyses o n throat swab specimens. These PCR results were found to have no detectable corr elation for clinical disease. The main outcome measures in this follow-up study were the reported prevalence of respiratory tract infections, asthma and allerg y. Results: Approximately 83%completed the follow-up questionnaire. No increas e in respiratory tract infections was reported by children previously found to h ave C. pneumoniae infection. A diagnosis of allergy was more common in the forme r PCR-negative population (13.4%vs 4.7%, p0.03). The differences were most a pparent in the population with atopic heredity. In a logistic regression model w ith different suggested risk factors for allergy, earlier infection with C. pneu moniae reduced the risk for allergy (OR = 0.13; 95%CI: 0.02-0.99). This was no t found for asthma. Conclusion: A positive PCR test for C. pneumoniae in young c hildren was associated with a lower risk of developing allergic airway disease i n this study population, and did not predict an increase in respiratory tract in fections.