Repurposing organic semiconducting nanomaterials to accelerate clinical translation of NIR-II fluorescence imaging
作者机构：Strait Laboratory of Flexible Electronics(SLoFE)Strait Institute of Flexible Electronics(SIFEFuture Technologies)Fujian Normal UniversityFuzhou 350117China Jiangxi Key Laboratory of NanobiomaterialsSchool of Materials Science and EngineeringEast China Jiaotong UniversityNanchang 330013China Frontiers Science Center for Flexible Electronics(FSCFE)MIIT Key Laboratory of Flexible Electronics(KLoFE)Northwestern Polytechnical UniversityXi’an 710072China
出 版 物：《Nano Research》 (纳米研究（英文版）)
年 卷 期：2023年第16卷第4期
页 面：5140-5154页
核心收录：
学科分类：07[理学] 070205[理学-凝聚态物理] 08[工学] 080501[工学-材料物理与化学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学]
基 金：supported by the Natural Science Foundation of Jiangxi Province(Nos.20212BAB214005 and 20212ACB214002) the Research startup fund of East China Jiaotong University(No.465)
主 题：organic semiconducting nanomaterials second near-infrared(NIR-II)fluorescence imaging malignant tumor organic injury infections
摘 要：Optical imaging possesses important implications for early disease diagnosis,timely disease treatment,and basic medical as well as biological *** with the traditionary near-infrared(NIR-I)window(650-950 nm)optical imaging,the emerging second near-infrared(NIR-II)window optical imaging technology owns the great superiorities of non-invasiveness,nonionizing radiation,and real-time dynamic imaging with the low biological interference,can significantly improve the tissue penetration depth and detection sensitivity,thus expecting to achieve accurate and precise diagnosis of major *** by the conspicuous superiorities,an increasing number of versatile NIR-II fluorophores have been legitimately designed and engineered for precisely deep-tissue mapping-mediated theranostics of life-threatening *** semiconducting nanomaterials(OSNs)are derived from organic conjugated molecules withπ-electron delocalized skeletons,which show greatly preponderant prospects in the biomedicine field due to the excellent photoelectric property,tunable energy bands,and fine *** this review,the superiorities of NIR-II fluorescence imaging using OSNs for brilliant visualization various of diseases,including tongue cancer,ovarian cancer,osteosarcoma,bacteria or pathogens infection,kidney dysfunction,rheumatoid arthritis,liver injury,and cerebrovascular function,are emphatically ***,the reasonable prospects and persistent efforts for repurposing OSNs to facilitate the clinical translation of NIR-II fluorescence phototheranostics are outlined.
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