Super-Resolution Displacement Spectroscopic Sensing over a Surface“Rainbow”

作     者：Lyu Zhou Nan Zhang Chang Chieh Hsu Matthew Singer Xie Zeng Yizheng Li Haomin Song Josep Jornet Yun Wu Qiaoqiang Gan Lyu Zhou;Nan Zhang;Chang Chieh Hsu;Matthew Singer;Xie Zeng;Yizheng Li;Haomin Song;Josep Jornet;Yun Wu;Qiaoqiang Gan

作者机构：Department of Electrical EngineeringThe State University of New York at BuffaloBuffaloNY 14260USA Department of Biomedical EngineeringThe State University of New York at BuffaloBuffaloNY 14260USA Department of Electrical and Computer EngineeringNortheastern UniversityBostonMA 02115USA Material Science Engineering ProgramKing Abdullah University of Science and TechnologyThuwal 23955-6900Saudi Arabia 

出 版 物：《Engineering》 (工程（英文）)

年 卷 期：2022年第17卷第10期

页      面：75-81页

核心收录：

学科分类：08[工学] 080203[工学-机械设计及理论] 0802[工学-机械工程] 

基　　金：supported by the National Science Foundation(ECCS-1807463 and PFI-1718177) UB Blue Sky program funding support from National Cancer Institute(NCI)of the National Institutes of Health(NIH)(R21CA235305) funded by NCI(P30CA16056) the support from National Science Foundation(CBET-1337860),which funds the nanoparticle tracking analysis system(Nano Sight,LM10,Malvern Instruments,Ltd.) 

主　　题：Rainbow trapping Metasurface Surface plasmon polaritons Super-resolution displacement On-chip biosensing 

摘      要：Subwavelength manipulation of light waves with high precision can enable new and exciting applications in spectroscopy,sensing,and medical *** these applications,miniaturized spectrometers are desirable to enable the on-chip analysis of spectral *** particular,for imaging-based spectroscopic sensing mechanisms,the key challenge is to determine the spatial-shift information accurately(i.e.,the spatial displacement introduced by wavelength shift or biological or chemical surface binding),which is similar to the challenge presented by super-resolution ***,we report a uniquerainbowtrapping metasurface for on-chip spectrometers and *** with super-resolution image processing,the low-setting 4×optical microscope system resolves a displacement of the resonant position within 35 nm on the plasmonic rainbow trapping metasurface with a tiny area as small as0.002 *** unique feature of the spatial manipulation of efficiently coupled rainbow plasmonic resonances reveals a new platform for miniaturized on-chip spectroscopic analysis with a spectral resolution of 0.032 nm in wavelength *** this low-setting 4×microscope imaging system,we demonstrate a biosensing resolution of 1.92×109exosomes per milliliter for A549-derived exosomes and distinguish between patient samples and healthy controls using exosomal epidermal growth factor receptor(EGFR)expression values,thereby demonstrating a new on-chip sensing system for personalized accurate bio/chemical sensing applications.