Tertiary lymphoid structures as unique constructions associated with the organization,education,and function of tumor-infiltrating immunocytes

作     者：Jing CHEN Jian CHEN Lie WANG Jing CHEN;Jian CHEN;Lie WANG

作者机构：Department of Gastrointestinal Surgerythe Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Institute of Immunology and Bone Marrow Transplantation Centerthe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Liangzhu LaboratoryZhejiang University Medical CenterHangzhou 311121China Cancer CenterZhejiang UniversityHangzhou 310058China 

出 版 物：《Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)》 (浙江大学学报（英文版）B辑（生物医学与生物技术）)

年 卷 期：2022年第23卷第10期

页      面：812-822页

核心收录：

学科分类：0710[理学-生物学] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100214[医学-肿瘤学] 0836[工学-生物工程] 10[医学] 

基　　金：supported by the Zhejiang Provincial Key Project of Research and Development(No.2019C03043) the National Natural Science Foundation of China(Nos.32030035,31870874,32000623,and 32100693) the Zhejiang Provincial Natural Science Foundation(No.LZ21C080001)of China。 

主　　题：Tertiary lymphoid structure(TLS) Tumor-infiltrating immunocyte Tumor microenvironment(TME) 

摘      要：Tertiary lymphoid structures(TLSs)are formations at sites with persistent inflammatory stimulation,including tumors.These ectopic lymphoid organs mainly consist of chemo-attracting B cells,T cells,and supporting dendritic cells(DCs).Mature TLSs exhibit functional organization for the optimal development and collaboration of adaptive immune response,delivering an augmented effect on the tumor microenvironment(TME).The description of the positive correlation between TLSs and tumor prognosis is reliable only under a certain condition involving the localization and maturation of TLSs.Emerging evidence suggests that underlying mechanisms of the anti-tumor effect of TLSs pave the way for novel immunotherapies.Several approaches have been developed to take advantage of intratumoral TLSs,either by combining it with therapeutic agents or by inducing the neogenesis of TLSs.