An iron-dependent form of non-canonical ferroptosis induced by labile iron

作     者：Yanmeng Li Qin Ouyang Wei Chen Ke Liu Bei Zhang Jingyi Yao Song Zhang Junying Ding Min Cong Anjian Xu 

作者机构：Beijing Clinical Research InstituteBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China Beijing Key Laboratory of Basic Research with Traditional Chinese Medicine on Infectious DiseasesBeijing Hospital of Traditional Chinese MedicineCapital Medical UniversityBeijing 100010China Liver Research CenterBeijing Friendship HospitalCapital Medical UniversityBeijing 100050China 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2023年第66卷第3期

页      面：516-527页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：supported by the Beijing Natural Science Foundation (7202034) the National Natural Science Foundation of China (82170614) 

主　　题：ferroptosis labile iron calcium overload mitochondrial calcium uniporter cell death oncosis apoptosis 

摘      要：Ferroptosis is a recently identified iron-dependent form of nonapoptotic cell death characterized by reactive oxygen species(ROS) generation and lipid ***,we report a novel iron-dependent form of ferroptosis induced by labile iron and investigate the mechanism underlying this *** find that labile iron-induced ferroptosis is distinct from canonical ferroptosis and is linked to the mitochondrial ***,the mitochondrial calcium uniporter mediates the ferroptosis induced by labile ***,cells undergoing labile iron-induced ferroptosis exhibit cytoplasmic features of oncosis and nuclear features of ***,labile iron-induced ferroptosis involves a unique set of ***,labile ironinduced ferroptosis was observed in liver subjected to acute iron overload in *** study reveals a novel form of ferroptosis that may be implicated in diseases caused by acute injury.