Hepatic manifestations of coronavirus disease 2019 infection:Clinical and laboratory perspective

作     者：Farina M Hanif Zain Majid Shoaib Ahmed Nasir H Luck Muhammed Mubarak 

作者机构：Department of HepatogastroenterologySindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of PathologySindh Institute of Urology and TransplantationKarachi 74200SindhPakistan 

出 版 物：《World Journal of Virology》 (世界病毒学杂志)

年 卷 期：2022年第11卷第6期

页      面：453-466页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

主　　题：COVID-19 Liver injury SARS-CoV-2 Clinical manifestations Liver function tests Cirrhosis 

摘      要：The novel coronavirus disease 2019(COVID-19)pandemic,caused by severe acute respiratory syndrome coronavirus 2,has become a global challenge of unprecedented nature since December *** most patients with COVID-19 exhibit mild clinical manifestations and upper respiratory tract involvement,in approximately 5%-10%of patients,the disease is severe and involves multiple organs,leading to multi-organ dysfunction and *** liver and gastrointestinal tract are also frequently involved in *** the context of liver involvement in patients with COVID-19,many key aspects need to be addressed in both native and transplanted *** review focuses on the clinical presentations and laboratory abnormalities of liver function tests in patients with COVID-19 with no prior liver disease,patients with pre-existing liver diseases and liver transplant recipients.A brief overview of the history of COVID-19 and etiopathogenesis of the liver injury will also be described as a prelude to better understanding the above aspects.