The molecular basis for ethnic variation and histological subtype differences in prostate cancer

作     者：ZONG Yang GOLDSTEIN Andrew S. HUANG JiaoTi 

作者机构：Howard Hughes Medical Institute University of California Departments of Molecular and Medical Pharmacology University of California Urology University of California Jonsson Comprehensive Cancer Center David Geffen School of Medicine University of California Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research University of California Pathology and Laboratory Medicine University of California 

出 版 物：《Science China(Life Sciences)》 (中国科学（生命科学英文版）)

年 卷 期：2013年第56卷第9期

页      面：780-787页

核心收录：

学科分类：0710[理学-生物学] 0830[工学-环境科学与工程（可授工学、理学、农学学位）] 1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Prostate Cancer Foundation the Broad Stem Cell Research Center at University of California, Los Angeles supported by the Department of Defense Prostate Cancer Research Program W81XWH-11-1-0227 (PI: Jiaoti Huang) W81XWH-12-1-0206 (PI: Lily Wu) UCLA SPORE in prostate cancer (PI: Robert Reiter) NCI 1R01CA158627 (PI: Leonard Marks) Stand-up-to-Cancer Dream Team Award (PI: Small and Witte) Prostate Cancer Foundation Honorable A. David Mazzone Special Challenge Award (PI: Robert Reiter) 

主　　题：前列腺癌 种族差异 组织学 分子基础 亚型 神经内分泌 西方国家 基因组学 

摘      要：Prostate cancer is a common malignancy among men in Western countries. Recently the morbidity and mortality of prostate cancer increase dramatically in several oriental countries including China. Rapidly evolving technology in molecular biology such as high-throughput sequencing and integrative analysis of genomic and transcriptomic landscapes have enabled the identification of key oncogenic events for prostate cancer initiation, progression and resistance to hormonal therapy. These surging data of prostate cancer genome also provide insights on ethnic variation and the differences in histological subtype of this disease. In this review, differences in the incidence of prostate cancer and the prevalence of main genetic alterations between Asian and Western populations are discussed. We also review the recent findings on the mechanisms underlying neuroendocrine differentiation of prostate cancer and the development of small cell neuroendocrine carcinoma after androgen deprivation therapy.