Modelling the impact of timelines of testing and isolation on disease control

作     者：Ao Li Zhen Wang Seyed M.Moghadas 

作者机构：Agent-Based Modelling LaboratoryYork UniversityTorontoOntarioM3J 1P3Canada 

出 版 物：《Infectious Disease Modelling》 (传染病建模（英文）)

年 卷 期：2023年第8卷第1期

页      面：58-71页

学科分类：1204[管理学-公共管理] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 100401[医学-流行病与卫生统计学] 0701[理学-数学] 10[医学] 

基　　金：support from Natural Sciences and Engineering Research Council of Canada(NSERC)through Individual Discovery Grant and EIDM Mathematics for Public Health(MfPH)grant 

主　　题：Testing Isolation Delay equations Simulations Turnaround time 

摘      要：Testing and isolation remain a key component of public health responses to both persistent and emerging infectious *** the value of these measures have been demonstrated in combating recent outbreaks including the COVID-19 pandemic and monkeypox,their impact depends critically on the timelines of testing and start of isolation during the course of *** investigate this impact,we developed a delay differential model and incorporated age-since-symptom-onset as a parameter for delay in *** then used the model to compare the outcomes of reverse-transcription polymerase chain reaction(RT-PCR)and rapid antigen(RA)testing methods when isolation starts either at the time of testing or at the time of test *** the model with estimates of SARS-CoV-2 infection and diagnostic sensitivity of the tests,we found that the reduction of disease transmission using the RA test can be comparable to that achieved by applying the RT-PCR *** constraints and inevitable delays associated with sample collection and laboratory assays in RT-PCR testing post symptom onset,self-administered RA tests with short turnaround times present a viable alternative for timely isolation of infectious cases.