Etiology of lung cancer: Evidence from epidemiologic studies

作     者：Kaiyong Zou Peiyuan Sun Huang Huang Haoran Zhuo Ranran Qie Yuting Xie Jiajun Luo Ni Li Jiang Li Jie He Briseis Aschebrook-Kilfoy Yawei Zhang 

作者机构：National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina Yale School of Public HealthNew HavenUnited States of America Department of Public Health Sciencesthe University of ChicagoChicagoUnited States of America 

出 版 物：《Journal of the National Cancer Center》 (癌症科学进展（英文）)

年 卷 期：2022年第2卷第4期

页      面：216-225页

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：supported by the Non-profit Central Research Insti-tute Fund of Chinese Academy of Medical Sciences(grant number:2021-RC310-009) 

主　　题：Lung cancer Etiology Epidemiologic study 

摘      要：Lung cancer is one of the leading causes of cancer incidence and mortality *** smoking,radon,air pollution,as well as occupational exposure to asbestos,diesel fumes,arsenic,beryllium,cadmium,chromium,nickel,and silica are well-established risk factors,many lung cancer cases cannot be explained by these known risk *** the last two decades the incidence of adenocarcinoma has risen,and it now surpasses squamous cell carcinoma as the most common histologic *** increase warrants new efforts to identify additional risk factors for specific lung cancer subtypes as well as a comprehensive review of current evidence from epidemiologic studies to inform future *** the myriad exposures individuals experience in real-world settings,it is essential to investigate mixture effects from complex exposures and gene-environment interactions in relation to lung cancer and its subtypes.