Estimating global prevalence,incidence,and outcomes of nonalcoholic fatty liver disease from 2000 to 2021:systematic review and meta-analysis

作     者：Jiaye Liu Ye Tian Xia Fu Chunyang Mu Menglin Yao Yinyun Ni Yong Liu Zhihui Li Jiaye Liu;Ye Tian;Xia Fu;Chunyang Mu;Menglin Yao;Yinyun Ni;Yong Liu;Zhihui Li

作者机构：Department of Thyroid and Parathyroid SurgeryWest China HospitalSichuan UniversityChengduSichuan 610000China Laboratory of Thyroid and Parathyroid DiseasesFrontiers Science Center for Disease-Related Molecular NetworkWest China HospitalSichuan UniversityChengduSichuan 610000China State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalSichuan University and Collaborative Innovation CenterChengduSichuan 610000China Respiratory Health InstituteFrontiers Science Center for Disease Molecular NetworkWest China HospitalSichuan UniversityChengduSichuan 610000China Department of UltrasoundWest China Hospital of Sichuan UniversityChengduSichuan 610000China Department of OutpatientsWest China HospitalSichuan UniversityChengduSichuan 610000China Department of Liver Surgery and Liver Transplantation CenterWest China HospitalSichuan UniversityChengduSichuan 610000China Department of Gastroenterological SurgeryWest China HospitalSichuan UniversityChengduSichuan 610000China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第14期

页      面：1682-1691页

核心收录：

学科分类：1002[医学-临床医学] 10[医学] 

基　　金：supported by the Department of Science and Technology of Sichuan Province(Nos.2020YJ0237,2021YFS0230,and 2020YFS0259) China Postdoctoral Science Foundation(No.2021M702340). 

主　　题：Incidence Non-alcoholic fatty liver disease Non-alcoholic steatohepatitis Outcome Prevalence 

摘      要：Background:The increasing burden of non-alcoholic fatty liver disease(NAFLD)worldwide imposes an emerging public health issue.We perform the current study to estimate the global prevalence,incidence,disease progression,and clinical outcomes of NAFLD.Methods:A systematic search was conducted in Medline,Embase,Web of Science,Google Scholar,and Cochrane CENTRAL that screened articles in English language published from January 2000 to December 2021.NAFLD prevalence,incidence,rate of disease progression,and outcomes were calculated with the DerSimonian-Laird random effects model with arcsine transformation.Results:Our search identified 59,156 records,of which 578 studies fulfilled our inclusion criteria.The overall prevalence of NAFLD was 29.38%(95%confidence interval[CI]28.09-30.69)regardless of the diagnostic techniques.Looking at the group in which the diagnosis was made by ultrasound exclusively,the pooled prevalence was 30.49%(95%CI 29.55-31.43).NAFLD has become more prevalent during the year 2011-2021(31.63%,95%CI 30.23-33.04)compared with year 2000-2010(27.94%,95%CI 26.23-29.69).The pooled estimation of non-alcoholic steatohepatitis prevalence was 8.26%(95%CI 1.13-21.01),46.49%(95%CI 35.93-57.20),and 46.72%(95%CI 37.57-55.98)in general population,NAFLD patients,and severe/morbidly obese patients,respectively.Based on a total of 110,142 newly developed NAFLD patients,the pooled incident rate was estimated as 46.24 cases per 1000 person-years(95%CI 43.21-49.30).In patients with NAFLD,the incident rate of hepatocellular carcinoma was 1.46(95%CI 0.90-2.03)cases per 1000 person-years.The overall pooled estimate of NAFLD related mortality was 23.91(95%CI 13.55-37.18)death per 1000 person-years.Conclusions:The prevalence of NAFLD is increasing globally.It is contributing to poor clinical outcomes including hepatocellular carcinoma and death.Rising awareness and urgent actions are warranted to control the NAFLD pandemic across the globe.Registration:PROSPERO,No.CRD42020171104.