A biomimetic gradient porous cage with a micro-structure for enhancing mechanical properties and accelerating osseointegration in spinal fusion

作     者：Cheng-Qi Jia Zhen Zhang Shi-Qi Cao Tian-Jiao Wang Hai-Chao Yu Wen-Xiang Wang Bo-Min Guo Xiong-Ying Qiu Yong-Gang You Fan-Qi Hu Jun Zhao Xue-Song Zhang 

作者机构：Medical School of Chinese PLABeijing100853China Department of OrthopedicsChinese PLA General HospitalBeijing100853China Department of Orthopedics of TCM Clinical Unit6th Medical CenterChinese PLA General HospitalBeijing100853China Research Institute of Aerospace Special Materials and Processing TechnologyBeijing100074China CAS Key Laboratory of Nanosystem and Hierarchical FabricationCAS Center for Excellence in NanoscienceNational Center for Nanoscience and TechnologyBeijing100190China Academy of Military Medical SciencesAcademy of Military SciencesBeijing100080China University of Chinese Academy of SciencesBeijing100049China 

出 版 物：《Bioactive Materials》 (生物活性材料（英文）)

年 卷 期：2023年第23卷第5期

页      面：234-246页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 08[工学] 0836[工学-生物工程] 

基　　金：国家自然科学基金 

主　　题：Biomimetic Porous Composite Osseointegration Spinal fusion 

摘      要：Objectives:Spinal fusion is a widely employed treatment of patients with degenerative disc disease,in which a cage is used to replace the disc for spinal *** it often fails for insufficient mechanical strength and poor ***,we designed a polyether-ether-ketone(PEEK)/tantalum(Ta)composite cage with a biomimetic gradient porous micro-structure,simultaneously enhancing mechanical properties and accelerating osseointegration in spinal *** and methods:In the study,based on the mechanical performances of PEEK and osteogenic potential of Ta,and the three-dimensional(3D)structures of cuttlebone and vertebra,the cages were respectively 3D printed by pure PEEK,PEEK with 5 wt%Ta(PEEK/Ta-5),PEEK with 10 wt%Ta(PEEK/Ta-10)and PEEK with 15 wt%Ta(PEEK/Ta-15),then verifiedin vitroand in sheep cervical fusion model ***:Vertebral Gyroid structure PEEK/Ta-15 cage exhibited superior mechanical properties than Cuttlebone-like structure PEEK/Ta-15 cage,closer to the cervical ***,PEEK/Ta-15 cage with higher Ta microparticles in PEEK provided a biomimetic gradient porous micro-structure with higher surface energy,guiding cell biological behavior,promoting new bone penetration,and accelerating osseointegrationin vivo.Conclusion:In conclusion,the study designed a biomimetic gradient porous cage with a micro-structure for enhancing mechanical properties,accelerating osseointegration and forming an anatomical lock in the fusion segment through composites,mechanical efficiency,surface extension,and pores.