Computed tomography perfusion in liver and spleen for hepatitis B virus-related portal hypertension:A correlation study with hepatic venous pressure gradient

作     者：Lei Wang Yu Zhang Yi-Fan Wu Zhen-Dong Yue Zhen-Hua Fan Chun-Yan Zhang Fu-Quan Liu Jian Dong 

作者机构：Department of Intervention TherapyBeijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Interventional RadiologyBeijing Shijitan HospitalCapital Medical UniversityBeijing 100038China Department of RadiologyBeijing Shijitan HospitalCapital Medical UniversityBeijing 100038China 

出 版 物：《World Journal of Gastroenterology》 (世界胃肠病学杂志（英文版）)

年 卷 期：2022年第28卷第42期

页      面：6068-6077页

核心收录：

学科分类：1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：the National Natural Science Foundation of China General Program No.81871461 

主　　题：Hepatic venous pressure gradient Portal hypertension Computed tomography perfusion Hepatitis B Liver cirrhosis 

摘      要：BACKGROUND Hepatic venous pressure gradient(HVPG)is the gold standard for diagnosis of portal hypertension(PH).However,its use can be limited because it is an invasive ***,it is necessary to explore a non-invasive method to assess *** To investigate the correlation of computed tomography(CT)perfusion of the liver with HVPG and Child-Pugh score in hepatitis B virus(HBV)-related *** Twenty-eight patients(4 female,24 male)with gastroesophageal variceal bleeding induced by HBV-related PH were recruited in our *** patients received CT perfusion of the liver before transjugular intrahepatic portosystemic stent-shunt(TIPS)*** parameters of CT perfusion of the liver,including liver blood flow(LBF),liver blood volume(LBV),hepatic artery fraction,splenic blood flow and splenic blood volume were *** was recorded during TIPS *** of liver perfusion with Child-Pugh score and HVPG were analyzed,and the receiver operating characteristic curve was *** on HVPG(12 mmHg vs≤12 mmHg),patients were divided into moderate and severe groups,and all parameters were *** Based on HVPG,18 patients were classified into the moderate group and 10 patients were classified into the severe *** Child-Pugh score,HVPG,LBF and LBV were significantly higher in the moderate group compared to the severe group(all P0.05).LBF and LBV were negatively associated with HVPG(r=-0.473,P0.05 and r=-0.503,P0.01,respectively),whereas splenic blood flow was positively associated with hepatic artery fraction(r=0.434,P0.05).LBV was negatively correlated with Child-Pugh ***-Pugh score was not related to *** a cutoff value of 17.85 mL/min/100 g for LBV,the sensitivity and specificity of HVPG≥12 mmHg for diagnosis were 80%and 89%,*** LBV and LBF were negatively correlated with HVPG and Child-Pugh *** perfusion imaging is a potential non-invasive quantitative predictor for PH i