Protective Effects of Six PPTs on Hypoxia/Reoxygenation Induced Cardiomyocyte Injury by Different Treatments
作者机构：Zhongshan Torch PolytechnicZhongshan 528436China Zhongshan Functional Cosmetics(Zhongshan Torch Polytechnic)Engineering Research CenterZhongshan 528436China Zhongshan Hospital of Traditional Chinese MedicineZhongshan 528400China
出 版 物：《Medicinal Plant》 (药用植物：英文版)
年 卷 期：2022年第13卷第5期
页 面：66-69,73页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：Supported by General Colleges and Universities Youth Innovative Talents Project of Guangdong Province(2019GKQNCX134) Guangdong Doctoral Workstation Funds
主 题：Protopanaxatriols(PPTs) Ginsenoside Rg1 Mitochondrial function Treatment process
摘 要：[Objectives]To detect the protective effects of six protopanaxatriols(PPTs)on hypoxia/reoxygenation(H/R)induced cardiomyocyte injury by different treatments.[Methods]The 3-[4,5-dimethylthiazol-2-yl]-2,5 diphenyl tetrazolium bromide(MTT)assay was used for detecting the protective effects of six PPTs including ginsenoside Rg1,Re,Rf,Rg2,(R)Rh1 and(S)Rh1 on cell viability reduced by H/R in different *** the adenosine triphosphate(ATP)content and mitochondrial membrane potential(MMP)were used for detecting the mitochondrial function change during PPTs treatment.[Results]Among six PPTs,ginsenoside Rg1,Re,Rf,Rg2 and(R)Rh1 at the concentration of 12.5μM significantly increased the cell survival when treated before and during H/*** five PPTs also significantly increased the ATP content and MMP reduced by H/R in the same *** comparison,only Rg1 significantly increased the cell viability compared with H/R group by pretreating and treating the cells during hypoxia process.[Conclusions]Different treatments affect the protective effects of *** treated before and during H/R,ginsenoside Rg1,Re,Rf,Rg2 and(R)Rh1 protect the cardiomyocyte against H/R injury mitochondrial function,and only ginsenoside Rg1 has protective effects when treated before and during hypoxia process.
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