Evaluation value of lung ultrasound combined with CRP and PCT on the efficacy and prognosis of HAP

作     者：Zeng Qinbing Chen Xiaojie Guan Jian Li Liming Liu Yijun Han Jiaqi Chao Yangong Zeng Qinbing;Chen Xiaojie;Guan Jian;Li Liming;Liu Yijun;Han Jiaqi;Chao Yangong

作者机构：Beijing Huaxin Hospital(The First Affiliated Hospital of Tsinghua University)Intensive care unit Wangjing Hospital Chinese Academy of Traditional Chinese Medicineemergency Beijing Huaxin Hospital(The First Affiliated Hospital of Tsinghua University)emergency 

出 版 物：《实用休克杂志（中英文）》 (Journal of Practical Shock)

年 卷 期：2022年第6卷第4期

页      面：247-256页

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学] 

基　　金：Science and Technology Innovation Project Fund of Chinese Academy of Chinese Medical Sciences(No.C12021A02907) 

主　　题：Lung ultrasound C-reactive protein Procalcitonin Hospital acquired pneumonia Curative effect Prognosis 

摘      要：Objective To investigate the efficacy of lung ultrasound combined with serum C-reactive protein(CRP)and procalcitonin(PCT)in evaluating the efficacy and prognosis of hospital-acquired pneumonia(HAP).Methods A total of 308 HAP patients admitted to the emergency department and intensive care unit(ICU)of First Affiliated Hospital of Tsinghua University from January 2018 to December 2021 were selected and divided into effective group(n=276)and ineffective group(n=32)according to different treatment *** baseline data and the dynamic changes of lung ultrasound score(LUS),CRP and PCT were compared between the two groups before treatment,3 days and 7 days after *** correlation analysis was used to evaluate the correlation between LUS,CRP,PCT and Clinical Pulmonary Infection Score(CPIS)after 3 days and 7 days of *** regression equation was used to analyze the related influencing factors of curative *** operating characteristic(ROC)curve and area under ROC(AUC)were used to analyze the efficacy of LUS,CPR,PCT and the combination of the three in predicting curative ***-Meier(K-M)survival curve was used to analyze the survival rate of patients with high-risk and low-risk LUS,CPR and *** In the effective group,the LUS,CPR and PCT after 3 days and 7 days of treatment were lower than those of the ineffective *** linear correlation analysis showed that LUS,CPR and PCT after 7 days of treatment were positively correlated with CPIS score(P0.05),among which LUS after 7 days of treatment had the strongest correlation with CPIS(r=0.635).Logistic regression analysis showed that LUS,CPR and PCT were correlated with the efficacy of HAP after 3 days and 7 days of treatment(P0.05).ROC curve analysis showed that the AUC of LUS,CPR and PCT predicting invalid HAP after 7 days of treatment was higher than that after 3 days of *** AUC of LUS combined with CPR and PCT after 7 days of treatment to predict the ef