White-light-driven fluorescence switch for super-resolution imaging guided photodynamic and photoacid therapy

作     者：Hao Chen Kaikai Wen Yu Lu Xin Zhang Yuhao Shi Qinqin Shi Han Ma Qian Peng Hui Huang 

作者机构：College of Materials Science and Opto-Electronic Technology&Center of Materials Science and Optoelectronics Engineering&CAS Center for Excellence in Topological Quantum Computation&CAS Key Laboratory of Vacuum PhysicsUniversity of Chinese Academy of SciencesBeijing100049China Department of Neurosurgery and Health Science CenterShenzhen Second People’s HospitalThe First Affiliated HospitalShenzhen UniversityShenzhen518035China School of Chemical SciencesUniversity of Chinese Academy of SciencesBeijing100049China Department of Dermatology&Guangdong Provincial Key Laboratory of Biomedical ImagingThe Fifth Affiliated Hospital Sun Yat-sen UniversityZhuhai519000China 

出 版 物：《Science China Chemistry》 (中国科学（化学英文版）)

年 卷 期：2022年第65卷第12期

页      面：2528-2537页

核心收录：

学科分类：1002[医学-临床医学] 1010[医学-医学技术（可授医学、理学学位）] 0703[理学-化学] 100215[医学-康复医学与理疗学] 10[医学] 

基　　金：supported by the Beijing Natural Science Foundation(Z210017) the National Natural Science Foundation of China(21774130,51925306) the National Key R&D Program of China(2018FYA 0305800) the Key Research Program of Frontier Sciences,Chinese Academy of Sciences(QYZDB-SSW-JSC046) the Strategic Priority Research Program Chinese Academy of Sciences(XDB28000000) University of Chinese Academy of Sciences 

主　　题：photocaged fluorophores super-resolution imaging type I/II photodynamic therapy photoacid therapy outcome self-report 

摘      要：Photocaged fluorophores with photoactivatable characteristics presented important applications in imaging the biological structures and *** advantage of their super-resolution imaging merits to manipulate and visualize anti-cancer treatment is always a goal of modern clinical *** photodynamic therapy(PDT) is a noninvasive treatment but limited in intracellular oxygen *** I PDT and photoacid therapy(PAT) are two effective supplements of traditional PDT especially in hypoxic ***,a novel white-light-driven fluorescence switch(7H-dibenzo[c,g]carbazol-7-yl)(2-iodophenyl)methanone(2IB) was designed and synthesized as an unprecedent “all in one platform for stochastic optical reconstruction microscopy(STORM) imaging guided Type Ⅰ/Ⅱ PDT and *** experimental and theoretical studies revealed that the working mechanism is based on two competing paths under excitation:photosensitization and photocyclization *** intersystem crossing(ISC) ensured the generation of reactive oxygen species(ROS) for PDT,while low energy barrier facilitated the photocyclization reaction that simultaneously yielded emissive fluorophores(2IBC) and H^(+) for super-resolution imaging and photoacid,***,the fluorescent intensity of mitochondria-targeted 2IBC was positively correlated with treatment efficacy,which is beneficial to spatiotemporally visualized therapeutic process and *** a result,superior anti-tumor performance was achieved in vitro and in *** contribution provided a multifunctional nanodrug paradigm for multimode cancer diagnosis and treatment.