A shifting adversary:control of pancreatic cancer transcriptomic subtypes
作者机构：Department of Basic MedicineTsinghua University School of MedicineBeijing 100084China
出 版 物：《Journal of Cancer Metastasis and Treatment》 (癌症转移与治疗（英文版）)
年 卷 期：2022年第8卷第1期
页 面：253-264页
学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学]
主 题：Pancreatic ductal adenocarcinoma transcriptional subtypes classical basal-like squamous quasi-mesenchymal cellular plasticity transcription factors tumor microenvironment
摘 要：Cellular plasticity,the dynamic ability of cells to adopt distinct transcriptional states,plays a well-known role in the pancreas during the initiation of pancreatic ductal adenocarcinoma(PDA),the most common form of pancreatic *** is now becoming clear that plasticity also plays an important role after the emergence of *** is composed of two major transcriptional subtypes,classical and basal-like,with important biological *** work has indicated that individual tumors can be comprised of cells of each subtype,and that tumor subtype can change during the evolution of a *** suggests that PDA cells can transit between transcriptional states,with important implications for disease *** review discusses what is currently known about inter-subtype plasticity and how this process is controlled.
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