Extension of the Lifespan of a Mouse Model of Rett Syndrome by Intracerebroventricular Delivery of MECP2

作     者：Kan Yang Cheng Cheng Yiting Yuan Yuefang Zhang Shifang Shan Zilong Qiu 

作者机构：Center for Excellence in Brain Science and Intelligence TechnologyInstitute of NeuroscienceState Key Laboratory of NeuroscienceCAS Key Laboratory of Primate NeurobiologyChinese Academy of SciencesShanghai 200031China Belief BioMed(Shanghai)Co.Ltd.Shanghai 200032China National Clinical Research Center for Aging and MedicineHuashan HospitalFudan UniversityShanghai 200040China 

出 版 物：《Neuroscience Bulletin》 (神经科学通报（英文版）)

年 卷 期：2023年第39卷第2期

页      面：297-302页

核心收录：

学科分类：0710[理学-生物学] 07[理学] 071006[理学-神经生物学] 

基　　金：supported by grants from the Youth Innovation Promotion Association Chinese Academy of Sciences(2022269) the Youth Science Fund of State Key Laboratory of Neuroscience(SKLN-2022B006) the National Natural Science Foundation of China(82001211,81941015,82021001) the CPSF-CAS Joint Foundation for Excellent Postdoctoral Fellows(2017LH036) the China Postdoctoral Science Foundation(2017M620173) the Strategic Priority Research Program of the Chinese Academy of Sciences(XDBS01060200) the Program of Shanghai Academic Research Leader,the Open Large Infrastructure Research of Chinese Academy of Sciences,the Shanghai Municipal Science and Technology Major Project(2018SHZDZX05) the Guangdong Key Scientific and Technological Project(2018B030335001) 

主　　题：MECP2 Extension neural 

摘      要：DearEditors,Rett Syndrome(RTT)is a severe neurodevelopmental disorder characterized by neural dysfunctions and a reduced lifespan,mainly in female patients,involving loss-of-function mutations in the methyl-CpG binding protein 2(MECP2)gene[1-4].