Association between thyroid hormone levels and frailty in the community-dwelling oldest-old: a cross-sectional study

作     者：Bo Guan Jiakun Luo Xin Huang Fan Tian Shasha Sun Yufei Ma Yan Yu Ruihan Liu Jian Cao Li Fan Bo Guan;Jiakun Luo;Xin Huang;Fan Tian;Shasha Sun;Yufei Ma;Yan Yu;Ruihan Liu;Jian Cao;Li Fan

作者机构：Geriatric Cardiology Department of the Second Medical Center and National Clinical Research Centerfor Geriatric DiseasesChinese People's Liberation Army General HospitalBeijing 100089China Medical School of People's Liberation Army General HospitalBejing 100089China 

出 版 物：《Chinese Medical Journal》 (中华医学杂志（英文版）)

年 卷 期：2022年第135卷第16期

页      面：1962-1968页

核心收录：

学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 100203[医学-老年医学] 10[医学] 

基　　金：funded by grants from NCRCG-PLAGH-2022004 the Military Healthcare Research Program(No.21BJZ26,18BJZ32) 

主　　题：Hypothyroidism Frailty Aging Thyroid hormone Oldest-old Triiodothyronin Thyroid stimulating hormone 

摘      要：Background:Changes in thyroid hormone levels are commonly recognized characters among the elderly,which were reported to potentially influence incident ***,we examined the cross-sectional associations of thyroid hormones(THs)with frailty as well as the five components characterizing frailty(fatigue,resistance,ambulation,number ofillnesses,and loss of weight)among the ***:Four hundred and eighty-seven community-dwelling oldest-old from a local community in Haidian District,Beijing,participated in our recruitment campaign between April 2019 and May *** primary outcomes were a definitive diagnosis of frailty according to the FRAIL scale(Fatigue,Resistance,Ambulation,Illnesses,Loss of weight)and a positive score for each frailty *** information(age,sex,marital status,and educational status),comorbidities,and details on the participants lifestyles were *** THs including free triodothyronin(fT3),triiodothyronine(T3),free thyroxine(fT4),and thyroxine(T4)and thyroid stimulating hormone(TSH)levels were also measured at the beginning of our *** regressions were conducted to screen for potential risk factors for frailty and its ***:Among the total 487 subjects at enrollment,60(12.23%)of them were diagnosed with subclinical hypothyroidism and 110(22.59%)of the total population scored positive for *** regression analyses adjusted for all potential confounders,showed that frailty was significantly associated with the serum TSH concentration(odds ratio[OR]:1.06),fT3 concentration(OR:0.54),and subclinical hypothyroidism score(OR:2.18).The association between fT4 and frailty was absent in our observational *** fT3/fT4 ratio characterizing peripheral hormone conversion was also tested to be correlated with ***:Subclinical hypothyroidism,higher TSH level,lower fT3 level,and decreased fT3/fT4 ratio were all associated with frailty assessed by the FRAIL scale among