Robust boron nanoplatform provokes potent tumoricidal activities via inhibiting heat shock protein

作     者：Yuying Zhao Ning Liu Piaoxue Liu Taojian Fan Rui Ma Huijie Hong Xiaojia Chen Zhongjian Xie Han Zhang Qi Wang Tongkai Chen Yuying Zhao;Ning Liu;Piaoxue Liu;Taojian Fan;Rui Ma;Huijie Hong;Xiaojia Chen;Zhongjian Xie;Han Zhang;Qi Wang;Tongkai Chen

作者机构：Science and Technology Innovation CenterGuangzhou University of Chinese MedicineGuangzhou 510405China Institute of Microscale OptoelectronicsCollaborative Innovation Centre for Optoelectronic Science&TechnologyKey Laboratory of Optoelectronic Devices and Systems of Ministry of Education and Guangdong ProvinceCollege of Physics and Optoelectronic EngineeringShenzhen Key Laboratory of Micro-Nano Photonic Information TechnologyGuangdong Laboratory of Artificial Intelligence and Digital Economy(SZ)Shenzhen UniversityShenzhen 518060China College of Health Science and Environmental EngineeringSchool of Shenzhen Technology UniversityShenzhen 518118China State Key Laboratory of Quality Research in Chinese MedicineInstitute of Chinese Medical SciencesUniversity of MacaoMacao 999078China Institute of PediatricsShenzhen Children’s HospitalShenzhen 518038China Shenzhen International Institute for Biomedical ResearchShenzhen 518116China 

出 版 物：《Asian Journal of Pharmaceutical Sciences》 (亚洲药物制剂科学（英文）)

年 卷 期：2022年第17卷第5期

页      面：728-740页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 1002[医学-临床医学] 07[理学] 070205[理学-凝聚态物理] 100214[医学-肿瘤学] 0702[理学-物理学] 10[医学] 

基　　金：the support from the Guangdong Basic and Applied Basic Research Foundation(2019B1515120043 and File no.2022A1515012154) the National Natural Science Foundation of China(File no.82104354 and File no.81960334) the Shenzhen Fundamental Research Program(File no.JCYJ20180507181817604) the Science and Technology Development Fund,Macao SAR(File no.0016/2021/A) 

主　　题：Mild photothermal therapy Chemotherapy Boron nanosheets Heat shock proteins Breast cancer 

摘      要：Near-infrared(NIR)-light-triggered photothermal therapy(PTT)is a promising treatment for breast cancer.However,its therapeutic efficiency is often compromised due to the heatinduced up-regulation of heat shock proteins,which confer photothermal resistance.To solve this urgent problem,PEGylated two-dimensional boron nanosheets(B-PEG)-which allow both multimodal imaging and photothermal conversion-were loaded with gambogic acid(GA),which can inhibit heat shock protein 90(Hsp90).Experimental findings indicated that this combination of B-PEG and GA could serve as an integrated drug delivery system for cancer diagnosis and treatment.It could be used to administer mild PTT as well as chemotherapy for breast cancer,provide improved anti-tumor effects,and reduce the toxicity of PTT,all while inhibiting breast cancer growth.This drug delivery system could offer a novel tool for administering chemotherapy combined with PTT while avoiding the adverse effects of traditional PTT.