Fine‑tuning genomic and pedigree inbreeding rates in equine population with a deep and reliable stud book:the case of the Pura Raza Española horse

作     者：Davinia Isabel Perdomo‑Gonzalez Nora Laseca Sebastian Demyda‑Peyras Mercedes Valera Isabel Cervantes Antonio Molina Davinia Isabel Perdomo-González;Nora Laseca;Sebastián Demyda-Peyrás;Mercedes Valera;Isabel Cervantes;Antonio Molina

作者机构：Departamento AgronomiaEscuela Tecnica Superior de Ingenieria AgromomicaUniversidad de SevillaCtra Utrera Km 141013 SevillaSpain Departamento de GeneticaUniversidad de CordobaCordobaSpain Facultad de Ciencias VeterinariasUniversidad Nacional de La PlataLa PlataArgentina Consejo Nacional de Investigaciones Cientificas y Tecnicas(CONICET)La PlataArgentina Departamento de Produccion AnimalFacultad de VeterinariaUniversidad Complutense de MadridMadridSpain. 

出 版 物：《Journal of Animal Science and Biotechnology》 (畜牧与生物技术杂志（英文版）)

年 卷 期：2023年第14卷第2期

页      面：515-528页

核心收录：

学科分类：0905[农学-畜牧学] 09[农学] 

基　　金：funded by the AGL-2017-84217-P Research project from Ministerio de Economia Industria y Competitividad Gobierno de Espana 

主　　题：Genomic inbreeding Horses Pedigree inbreeding 

摘      要：Background:Estimating inbreeding,which is omnipresent and inevitable in livestock populations,is a primary goal for management and animal breeding especially for those interested in mitigating the negative consequences of *** coefficients have been historically estimated by using pedigree information;however,over the last decade,genome-base inbreeding coefficients have come to the forefront in this *** Pura Raza Espanola(PRE)horse is an autochthonous Spanish horse breed which has been recognised since *** total PRE population(344,718 horses)was used to estimate Classical(F),Ballou’s ancestral,Kalinowski’s ancestral,Kalinowski’s new and the ancestral history coefficient *** addition,genotypic data from a selected population of 805 PRE individuals was used to determine the individual inbreeding coefficient using SNP-by-SNP-based techniques(methods of moments-FHOM-,the diagonal elements of the genomic-FG-,and hybrid matrixes-FH-)and ROH measures(FRZ).The analyse of both pedigree and genomic based inbreeding coefficients in a large and robust population such as the PRE horse,with proven parenteral information for the last 40 years and a high degree of completeness(over 90%for the last 70 years)will allow us to understand PRE genetic variability better and the correlations between the estimations will give the data greater ***:The mean values of the pedigree-based inbreeding coefficients ranged from 0.01(F for the last 3 generations-F3-)to 0.44(ancestral history coefficient)and the mean values of genomic-based inbreeding coefficients varied from 0.05(FRZ for three generations,FH and FHOM)to 0.11(FRZ for nine generations).Significant correlations were also found between pedigree and genomic inbreeding values,which ranged between 0.58(F3 with FHOM)and 0.79(F with FRZ).In addition,the correlations between FRZ estimated for the last 20 generations and the pedigree-based inbreeding highlight the fact that fewer generations of