Role of Akkermansia muciniphila in the development of nonalcoholic fatty liver disease: current knowledge and perspectives

作     者：Yuqiu Han Lanjuan Li Baohong Wang Yuqiu Han;Lanjuan Li;Baohong Wang

作者机构：State Key Laboratory for Diagnosis and Treatment of Infectious DiseasesNational Clinical Research Center for Infectious DiseasesCollaborative Innovation Center for Diagnosis and Treatment of Infectious DiseasesThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Research Units of Infectious disease and MicroecologyChinese Academy of Medical SciencesHangzhou 310003China Jinan Microecological Biomedicine Shandong LaboratoryJinan 250117China 

出 版 物：《Frontiers of Medicine》 (医学前沿（英文版）)

年 卷 期：2022年第16卷第5期

页      面：667-685页

核心收录：

学科分类：1002[医学-临床医学] 1001[医学-基础医学(可授医学、理学学位)] 10[医学] 

基　　金：This study was supported by National Natural Science Foundation of China(Nos.82170668,81790633,and 81790630) Sino-German Center for Research Promotion(No.GZ1546) CAMS Innovation Fund for Medical Sciences(No.2019-I2M-5-045) Jinan Microecological Biomedicine Shandong Laboratory(No.JNL-2022040C). 

主　　题：Akkermansia muciniphila NAFLD NASH steatosis inflammation 

摘      要：Nonalcoholic fatty liver disease(NAFLD)is a hepatic manifestation of metabolic syndrome and a common cause of liver cirrhosis and cancer.Akkermansia muciniphila(A.muciniphila)is a next-generation probiotic that has been reported to improve metabolic disorders.Emerging evidence indicates the therapeutic potential of A.muciniphila for NAFLD,especially in the inflammatory stage,nonalcoholic steatohepatitis.Here,the current knowledge on the role of A.muciniphila in the progression of NAFLD was summarized.A.muciniphila abundancy is decreased in animals and humans with NAFLD.The recovery of A.muciniphila presented benefits in preventing hepatic fat accumulation and inflammation in NAFLD.The details of how microbes regulate hepatic immunity and lipid accumulation in NAFLD were further discussed.The modulation mechanisms by which A.muciniphila acts to improve hepatic inflammation are mainly attributed to the alleviation of inflammatory cytokines and LPS signals and the downregulation of microbiota-related innate immune cells(such as macrophages).This review provides insights into the roles of A.muciniphila in NAFLD,thereby providing a blueprint to facilitate clinical therapeutic applications.