Christmas Tree-Shaped Microneedles as FOLFIRINOX Spatiotemporal Delivery System for Pancreatic Cancer Treatment

作     者：Danqing Huang Xiao Fu Xiaoxuan Zhang Yuanjin Zhao Danqing Huang;Xiao Fu;Xiaoxuan Zhang;Yuanjin Zhao

作者机构：Institute of Translational MedicineThe Afiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing210002China Oujiang Laboratory(Zhejiang Lab for Regenerative MedicineVision and Brain Health)Wenzhou InstituteUniversity of Chinese Academy of SciencesWenzhouZhejiang 325000China State Key Laboratory of BioelectronicsSchool of Biological Science and Medical EngineeringSoutheast UniversityNanjing 210096China 

出 版 物：《Research》 (研究（英文）)

年 卷 期：2023年第2022卷第2期

页      面：177-186页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：This work was supported by the National Key Research and Development Program of China(grant number 2020YFA0908200) the National Natural Science Foundation of China(grant numbers 52073060,61927805) the Guangdong Basic and Applied Basic Research Foundation(grant number 2021B1515120054) the Shenzhen Fundamental Research Program(grant numbers JCYJ20190813152616459,JCYJ20210324133214038) 

主　　题：FOLFIRI chemotherapy Cancer 

摘      要：As an effective combination chemotherapy,FOLFIRINOX regimen(fluorouracil,leucovorin,irinotecan,and oxaliplatin)has shown definite antitumor eficacy for treating pancreatic cancer(PC)***,the traditional systematic administration of these chemotherapeutics limits the drug targeting and causes unwanted effects.