Correlation between imaging features on computed tomography and combined positive score of PD-L1 expression in patients with gastric cancer

作     者：Zhilong Wang Yinkui Wang Xiaoting Li Yanling Li Zhaode Bu Zhongwu Li Yingshi Sun Jiafu Ji Zhilong Wang;Yinkui Wang;Xiaoting Li;Yanling Li;Zhaode Bu;Zhongwu Li;Yingshi Sun;Jiafu Ji

作者机构：Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Department of RadiologyBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Center of Gastrointestinal SurgeryBeijing 100142China Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education/Beijing)Department of PathologyPeking University Cancer Hospital&InstituteBeijing 100142China 

出 版 物：《Chinese Journal of Cancer Research》 (中国癌症研究（英文版）)

年 卷 期：2022年第34卷第5期

页      面：510-518页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Digestive Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals(No.XXT20) 

主　　题：Gastric cancer computed tomography combined positive score 

摘      要：Objective:To explore the correlation between computed tomography(CT)features and combined positive score(CPS)of programmed cell death ligand 1(PD-L1)expression in patients with gastric cancer(GC).Methods:This study reviewed an institutional database of patients who underwent GC operation without neoadjuvant chemotherapy between December 2019 and September *** CPS results of PD-L1 expression of postoperative histological examination were recorded by *** CT features were measured,and their correlation with CPS 5 or 10 score groups of PD-L1 expression was ***:Data for 153 patients with GC were *** them,124 were advanced GC patients,and 29were early GC *** of the CT features significantly differed between CPS groups with a cutoff score of 5and a score of 10 in patients with early *** advanced GC,the presence of lymph nodes with short diameters10mm was significantly different(P=0.024)between the CPS10 mm significantly differed between the CPS10 and CPS≥10 groups in advanced *** sensitivity,specificity and area under receiver operating characteristic(ROC)curve of logistic regression model for predicting CPS≥10 was 71.7%,50.0%and 0.671,*** instability(MSI)status was significantly different in CPS groups with cutoff score of 5 and 10 in advanced GC ***:CT findings of advanced GC patients with CPS≥10 showed greater arterial phase enhancement and larger lymph *** has the potential to help screen patients suitable for immunotherapy.