Biological investigation of phenyl benzoate, benzophenone, and xanthone compounds

作     者：Beidou Zhou Chun Lei Xuemei Liao Hang Zhu Zhipeng Ruan Yuanyuan Fang Guifen Xu Yuli Chen 周北斗;雷春;廖雪梅;朱航;阮志鹏;方圆圆;许桂芬;陈玉丽

作者机构：School of Pharmacy and Medical TechnologyPutian UniversityKey Laboratory of Pharmaceutical Analysis and Laboratory Medicine(Putian University)Fujian Provincial UniversityPutian 351100China School of PharmacyFujianMedical UniversityFuzhou350108China Fujian Tianquan Pharmaceutical Co.Ltd.Longyan 364000China 

出 版 物：《Journal of Chinese Pharmaceutical Sciences》 (中国药学（英文版）)

年 卷 期：2022年第31卷第10期

页      面：738-745页

核心收录：

学科分类：1007[医学-药学(可授医学、理学学位)] 10[医学] 

基　　金：Natural Science Foundation of Fujian Province (Grant No. 2022J011158) Putian City Science and Technology Plan Project (Grant No. 2021S2001-9) Fujian Provincial Key Laboratory of Innovative Drug Target Research (Grant No. FJ-YW-2021KF01) 

主　　题：Phenyl benzoate Benzophenone Xanthone Antibacterial Antifungal α-Glycosidase 

摘      要：In the present study, we evaluated the antitumor, anti-tyrosinase, anti-pancreatic lipase, antibacterial, antifungal, and anti-α-glycosidase activities for all or a subset of 20 known compounds. They included 8 phenyl benzoates, 10 benzophenones, and 2 xanthones. Phenyl benzoate compounds 1–8 did not exhibit evident antitumor activity, which was consistent with existing theories. Compounds 16, 17, and 18 exhibited moderate anti-tyrosinase activity. In addition, compounds 11 and 18 exhibited moderate inhibitory activity against Candida albicans, and compound 20 exhibited stronger anti-α-glycosidase activity than quercetin, with an IC_(50)of approximately 2.45 μM. These results demonstrated that compounds 11, 16–18, and 20 were promising leads for further structural modification.