One-step PDA coating strategy on pure Zn for blood-contacting engineering

作     者：Xiaoyun Qi Shicheng Zhou Hui Fang Shuhan Yang Chunjin Hang Yanhong Tian Chenxi Wang Xiaoyun Qi;Shicheng Zhou;Hui Fang;Shuhan Yang;Chunjin Hang;Yanhong Tian;Chenxi Wang

作者机构：State Key Laboratory of Advanced Welding and JoiningHarbin Institute of TechnologyHarbin 150001China 

出 版 物：《Journal of Materials Science & Technology》 (材料科学技术（英文版）)

年 卷 期：2022年第123卷第28期

页      面：78-91页

核心收录：

学科分类：0710[理学-生物学] 080503[工学-材料加工工程] 08[工学] 0805[工学-材料科学与工程（可授工学、理学学位）] 0836[工学-生物工程] 

基　　金：financially supported by the National Natural Science Foundation of China(No.51975151) the Heilongjiang Provincial Natural Science Foundation of China(No.LH2019E041) the Heilongjiang Touyan Innovation Team Program。 

主　　题：Biodegradable Pure Zn Uniform corrosion Blood compatibility Doubled-coated structure 

摘      要：The mechanical performance degradation caused by pitting corrosion and the insufficient biocompatibility induced with ion release inhibit the application of Zn as the new biodegradable metallic materials for blood-contacting intervention therapy.This work successfully coats a uniform polydopamine(PDA)layer on pure Zn via a one-step deposition process without introducing heavy metal elements or detrimental additives.Enhanced corrosion resistance and uniform corrosion have been performed on PDA coated Zn with corrosion products and pits reduced significantly than pure Zn during in vitro degradation.Thrombosis could be prohibited by anticoagulation performance with prothrombin time and activated partial thromboplastin time prolonged after co-incubation,and an almost 40%decrease of platelets adhesion,indicating the improved blood compatibility of coated Zn.Additionally,the poly(lactic-co-glycolic acid)(PLGA)is filmed on PDA coated Zn to realize a smooth double-coated structure with superior mechanical performance under stress loading to stably serve the multifunctional application,such as drug loading.Our strategy not only represents a facile and biological friendly method for Zn surface modification but also puts forward new ideas on preparing PDA-based coatings on active biodegradable alloys,which are beneficial for better blood-contacting engineering.