Right time to detect urine iodine during papillary thyroid carcinoma diagnosis and treatment:A case report

作     者：Shi-Chang Zhang Cheng-Jing Yan Yun-Fei Li Ting Cui Mei-Ping Shen Jie-Xin Zhang 

作者机构：Department of Laboratory MedicineThe First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina Department of General SurgeryThe First Affiliated Hospital with Nanjing Medical UniversityNanjing 210029Jiangsu ProvinceChina 

出 版 物：《World Journal of Clinical Cases》 (世界临床病例杂志)

年 卷 期：2022年第10卷第30期

页      面：11010-11015页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：Supported by the“The Six Top Talent Project”of Jiangsu Province,No.WSW-004 the Key Laboratory for Laboratory Medicine of Jiangsu Province of China,No.ZDXKB2016005 

主　　题：Papillary thyroid carcinoma Urine iodine concentration Iodinated contrast media As^(3+)-Ce^(4+)catalytic spectrophotometry 

摘      要：BACKGROUND This is the first documentation of a spontaneous and nonspecific chemical reaction of an iodinated contrast media with ammonium persulfate used in As3+-Ce4+catalytic spectrophotometry for urine iodine concentration(UIC)*** SUMMARY We herein report an incidental case who had a dual source computed tomography examination for papillary thyroid carcinoma *** spot urine specimens were collected during her hospitalization and were measured by As3+-Ce4+catalytic spectrophotometry on a Beckman Coulter *** reacted solutions were“brownish,and the results showed extremely high iodine concentrations despite serial *** patient claimed no dietary habit of iodized salt or iodine-containing medical history,which strongly pointed to iodinated contrast media(ICM)via intravenous *** with 0.01%ICM,its interruption is still profound on the desired urine iodine reaction with ammonium persulfate,leading to inaccurate UIC and possibly inappropriate *** The following laboratory suggestions should be considered:(1)As3+-Ce4+catalytic spectrophotometry is only suitable for UIC measurement after confirmed ICM renal clearance;(2)A mass spectrometry-based method can be applied as an alternative during the ICM clearance period;and(3)The UIC baseline can be confirmed after ICM injection by consecutive detection for at least 2 mo.