Natural killer cell-triggered vascular transformation:maternal care before birth?

作     者：Jianhong Zhang Zhilin Chen Graeme N Smith B.Anne Croy 

作者机构：Department of Anatomy and Cell BiologyQueen’s UniversityKingstonONCanada Department of Obstetrics and GynecologyQueen’s UniversityKingstonONCanada 

出 版 物：《Cellular & Molecular Immunology》 (中国免疫学杂志（英文版）)

年 卷 期：2011年第8卷第1期

页      面：1-11页

核心收录：

学科分类：1002[医学-临床医学] 100214[医学-肿瘤学] 10[医学] 

基　　金：These studies were supported by awards from the Natural Sciences and Engineering Research Council Canada the Canadian Institutes of Health Research and the Canada Research Chairs Program to BAC and a Province of Ontario/Queen’s Postdoctoral Fellowship award to JHZ 

主　　题：decidua humanized mice pregnancy uterine natural killer cell 

摘      要：Natural killer(NK)cells are found in lymphoid and non-lymphoid *** addition to important roles in immune surveillance,some NK cells contribute to angiogenesis and circulatory *** uterus of early pregnancy is a non-lymphoid organ enriched in NK cells that are specifically recruited to placental attachment *** species with invasive hemochorial placentation,these uterine natural killer(uNK)cells,via secretion of cytokines,chemokines,mucins,enzymes and angiogenic growth factors,contribute to the physiological change of mesometrial endometrium into the unique stromal environment called decidua *** humans,uNK cells have the phenotype CD56^(bright) CD16^(dim) and they appear in great abundance in the late secretory phase of the menstrual cycle and early *** expression studies indicate that CD56^(bright) CD16^(dim) uterine and circulating cells are functionally *** humans but not mice or other species with post-implantation decidualization,uNK cells may contribute to blastocyst implantation and are of interest as therapeutic targets in female *** and genetic studies in mice first identified triggering of the process of gestation spiral arterial modification as a major uNK cell function,achieved via interferon(IFN)-c *** spiral arterial modification,branches from the uterine artery that traverse the endometrium/decidua transiently lose their muscular coat and ability to *** expression of vascular markers changes from arterial to venous as these vessels dilate and become low-resistance,high-volume *** understanding of the vascular interactions of human uNK cells is difficult to obtain because endometrial time-course studies are not possible in pregnant *** we briefly review key information concerning uNK cell functions from studies in rodents,summarize highlights concerning human uNK cells and describe our preliminary studies on development of a humanized,pregnant