Development of functional antibodies against influenza B virus by activation-induced cytidine deaminase in hybridoma cells

作     者：Yuanzhi Chen Chenguang Shen Jing Chen Junyu Chen Fentian Chen Limin Zhang Xue Liu Siyuan Chen Sen Xue Yongliang Liu Jixian Tang Quan Yuan Yixin Chen Wenxin Luo Ningshao Xia Yuanzhi Chen;Chenguang Shen;Jing Chen;Junyu Chen;Fentian Chen;Limin Zhang;Xue Liu;Siyuan Chen;Sen Xue;Yongliang Liu;Jixian Tang;Quan Yuan;Yixin Chen;Wenxin Luo;Ningshao Xia

作者机构：National Institute of Diagnostics and Vaccine Development in Infectious DiseasesState Key Laboratory of Molecular Vaccinology and Molecular DiagnosticsSchool of Public Health&School of Life ScienceXiamen UniversityXiamen 361102China Biosafety Level-3 LaboratorySchool of Public HealthSouthern Medical UniversityGuangzhou 510515China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2022年第37卷第4期

页      面：619-622页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100102[医学-免疫学] 10[医学] 

基　　金：the National Natural Science Foundation of China(31870925) Shenzhen Science and Technology Innovation Commission for Research and Development Project(JCYJ20190809183205622) Guangdong Basic and Applied Basic Research Foundation(2020A1515010368)。 

主　　题：influenza activation globally 

摘      要：Dear Editor,Influenza B viruses(IBVs)have circulated among humans for more than 80 years.Seasonal influenza virus epidemics caused by two IBV lines(Victoria and Yamagata)and influenza A virus have considerable effects on public health globally and result in approximately290,000–650,000 annual influenza-attributed deaths(Caini et al.,2015;Pan et al.,2015).Currently,the most effective countermeasures against influenza B virus infections are influenza virus vaccines(Subbarao and Matsuoka,2013).However,these vaccines have limited efficacy because only strain-matched humoral immune responses are induced.