The facile method developed for preparing polyvinylidene fluoride plasma separation membrane via macromolecular interaction

作     者：Juanjuan Liu Xiaolong Lu Guiming Shu Ke Li Shuyun Zheng Xiao Kong Tao Li Jun Yang Juanjuan Liu;Xiaolong Lu;Guiming Shu;Ke Li;Shuyun Zheng;Xiao Kong;Tao Li;Jun Yang

作者机构：Tianjin Key Laboratory of Extracorporeal Life Support for Critical DiseasesTianjin Artificial Cell Engineering Technology Research CenterInstitute of Hepatobiliary DiseaseThe Third Central Hospital Affiliated to Nankai UniversityTianjin Third Central HospitalTianjin 300170China State Key Laboratory of Separation Membrane and Membrane ProcessesSchool of Material Science and EngineeringInstitute of Biological and Chemical EngineeringTiangong UniversityTianjin 300387China Clinical LaboratoryTianjin Children’s HospitalTianjin 300074China State Key Laboratory of Membrane Materials and Membrane ApplicationsTianjin Motimo Membrane Tech.Co.LtdTianjin 300457China The Key Laboratory of Bioactive MaterialsCollege of Life ScienceNankai UniversityTianjin 300000China 

出 版 物：《Chinese Journal of Chemical Engineering》 (中国化学工程学报（英文版）)

年 卷 期：2022年第35卷第9期

页      面：140-149页

核心收录：

学科分类：0831[工学-生物医学工程（可授工学、理学、医学学位）] 0710[理学-生物学] 080706[工学-化工过程机械] 1002[医学-临床医学] 08[工学] 0807[工学-动力工程及工程热物理] 0805[工学-材料科学与工程（可授工学、理学学位）] 0702[理学-物理学] 

基　　金：the National Natural Science Foundation of China (21776216) Tianjin Key Laboratory Project (16PTSYJC00210) Program for Innovative Research Team in University of Tianjin (TD13-5044) Science and technology support project of Tianjin (20YFZCSY00310, 21ZXGWSY00040) State Key Laboratory of Separation Membranes and Membrane Processes (Tiangong University), Youth Science Foundation of Tianjin (21JCQNJC00100) Tianjin Health Science and Technology Project (TJWJ2021MS014)。 

主　　题：Membranes Macro-pore plasma separation membrane Hemocompatibility Purification Biomedical engineering 

摘      要：The design of membrane pore is critical for membrane preparation. Polyvinylidene fluoride(PVDF) membrane exhibits outstanding properties in the water-treatment field. However, it is a huge challenge to prepare PVDF macro-pore plasma separation membrane by non-solvent induced phase separation(NIPS). Herein, a facile strategy is proposed to prepare PVDF macro-pore plasma separation membrane via macromolecular interaction. ATR-FTIR and ^(1)H NMR showed that the intermolecular interaction existed between polyethylene oxide(PEO) and polyvinylpyrrolidone(PVP). It could significantly affect the PVDF macro-pore membrane structure. The maximum pore of the PVDF membrane could be effectively adjusted from small-pore/medium-pore to macro-pore by changing the molecular weight of PEO. The PVDF macro-pore membrane was obtained successfully when PEO-200 k existed with PVP. It exhibited higher plasma separation properties than the currently used plasma separation membrane.Moreover, it had excellent hemocompatibility due to the similar plasma effect, hemolysis, prothrombin time, blood effect and complement C_(3a) effect with the current utilized plasma separation membrane,implying its great potential application. The proposed facile strategy in this work provides a new method to prepare PVDF macro-pore plasma separation membrane by NIPS.