A pair of SARS-CoV-2 nucleocapsid protein monoclonal antibodies shows high specificity and sensitivity for diagnosis

作     者：An-Kai Zhu Sa-Sa Li Shu-Pei Yu Zhao-Yong Zhang Huan Li Jing-Feng Li Shan-Shan Gao Heng Chen Jincun Zhao Run Shi Mingjian Lu Chaoyang Li An-Kai Zhu;Sa-Sa Li;Shu-Pei Yu;Zhao-Yong Zhang;Huan Li;Jing-Feng Li;Shan-Shan Gao;Heng Chen;Jincun Zhao;Run Shi;Mingjian Lu;Chaoyang Li

作者机构：Affiliated Cancer Hospital and Institute of Guangzhou Medical UniversityState Key Laboratory of Respiratory DiseaseKey Laboratory for Cell Homeostasis and Cancer Research of Guangdong High Education InstituteGuangzhou510095China State Key Laboratory of Respiratory DiseaseNational Clinical Research Center for Respiratory DiseaseGuangzhou Institute of Respiratory HealthThe First Affiliated Hospital of Guangzhou Medical UniversityGuangzhou510182China Department of Interventional RadiologyAffiliated Cancer Hospital and Institute of Guangzhou Medical UniversityGuangzhou510095China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2022年第37卷第6期

页      面：942-945页

核心收录：

学科分类：0710[理学-生物学] 1001[医学-基础医学(可授医学、理学学位)] 100103[医学-病原生物学] 10[医学] 

基　　金：supported by grants from MOST(2018YFA0507201 to CL) from the National Natural Science Foundation of China(32070147 to CL) from Guangzhou Key Medical Discipline Construction Project 

主　　题：al. diagnosis specificity 

摘      要：Dear Editor,Severe Acute Respiratory Syndrome Coronavirus Type 2(SARS-CoV-2) is the pathogen of the coronavirus disease 2019(COVID-19), which has spread worldwide.SARS-CoV-2 is an enveloped virus belongs to the family of β-coronavirus(Xu et al., 2020). Its genome is a linear single-stranded positive-sense RNA about 30,000 nucleotides packed inside a virion with a diameter of 100 nm and a volume of about 10^(6)nm^(3)(Bar-On et al., 2020).