对荷兰1993—2000年间患腹腔疾病的儿童进行全国前瞻性研究:认识增强和临床表现改变
A national prospective study on childhood celiac disease in the netherlands 1993-2000: An increasing recognition and a changing clinical picture作者机构：Leiden University Medical Center Department of Pediatrics J6-S-220 PO Box 9600 230 0 RC Leiden Netherlands Dr.
出 版 物：《世界核心医学期刊文摘（儿科学分册）》 (Dkgest of the World Latest Medical Information)
年 卷 期：2006年第2卷第1期
页 面：31-31页
学科分类：1002[医学-临床医学] 100202[医学-儿科学] 10[医学]
主 题：长期腹泻 小肠黏膜 儿科医生 发育不良 前瞻性调查 公共健康
摘 要：Objectives: To investigate prospectively whether the incidence of diagnosed ce liac disease (CD) is increasing in the Netherlands and whether the clinical pres entation is changing. Study design: All newly diagnosed cases of CD throughout t he Netherlands were registered prospectively from 1993 to 2000. The clinical pic ture was compared with that noted in our former study (1975-1990). Results: The overall incidence rate of CD was 0.81/1000 live births, with a linear increase from 1993 to 2000. There was a significant increase in the number of subjects wi th partial villous atrophy of the small bowel mucosa. The clinical presentation has changed significantly: abdominal distention, chronic diarrhea, and failure t o thrive are less common, and more children presented with weight P10, abdomin al pain, and lassitude. The median age at diagnosis also increased. Conclusion: The recognition of childhood CD in the Netherlands has increased significantly d uring the last few years, and the clinical picture has changed as well. Our data may indicate an increasing awareness of the Dutch doctors working in Child Publ ic Health, general practitioners, and pediatricians to recognize more subtle exp ressions of the disease.
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