Epidemiological characteristics and disease burden of infectious mononucleosis in hospitalized children in China:A nationwide retrospective study

作     者：Mengjia Liu Xinyu Wang Linlin Zhang Guoshuang Feng Yueping Zeng Ran Wang Zhengde Xie Mengjia Liu;Xinyu Wang;Linlin Zhang;Guoshuang Feng;Yueping Zeng;Ran Wang;Zhengde Xie

作者机构：Beijing Key Laboratory of Pediatric Respiratory Infectious DiseasesKey Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesLaboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing100045China Research Unit of Critical Infection in Children2019RU016Chinese Academy of Medical SciencesBeijingChina Big Data CenterBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing100045China Medical Record Management OfficeBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing100045China 

出 版 物：《Virologica Sinica》 (中国病毒学（英文版）)

年 卷 期：2022年第37卷第5期

页      面：637-645页

核心收录：

学科分类：0710[理学-生物学] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 100202[医学-儿科学] 100401[医学-流行病与卫生统计学] 10[医学] 

基　　金：supported by the National Natural Science Foundation of China (82002130) supported by the CAMS Innovation Fund for Medical Sciences (2019-I2M-5-026) 

主　　题：Epstein-Barr virus(EBV) Infectious mononucleosis(IM) Children Epidemiological characteristics Disease burden 

摘      要：Epstein-Barr virus(EBV)is very common,with the infection rate in adults over 90%worldwide.Infectious mononucleosis(IM)is caused by primary infection with EBV.Most IM patients are generally considered to have a favorable prognosis,but a few patients will also develop complications.Children with severe symptoms will require hospitalization.However,the disease burden of children hospitalized with IM in China has been rarely described.In this study,we included the Face sheets of discharge medical records from 27 member children s hospitals of Futang Research Center of Pediatric Development from Jan 1st,2016 to Dec 31st,2020,and medical information such as gender,age,region,time of admission,length of stay and expenditure were extracted.There were 24,120 IM cases,which accounted for 0.42%(24,120/5,693,262)of all hospitalized cases during this period.The ratio of male to female was 1.48:1.Hospitalization for IM in the 4-6 years age group was the highest among inpatients of all age groups.Case numbers increased year by year between 2016 and 2020,and the monthly hospitalization was generally high from Jul to Sep but reduced from Jan to Feb per year.Bronchitis/pneumonia and hepatic dysfunction were two common complications in hospitalized IM patients.The median length of stay was 8 days,and the median cost of hospitalization was 970.59 US dollars.This study will help understand the epidemiological characteristics and disease burden of hospitalized children with IM in China.