Leptin signaling and leptin resistance
作者机构：Department of AnatomyHistology and EmbryologySchool of Basic Medical SciencesHealth Science CenterPeking UniversityBeijing 100191China Neuroscience Research InstitutePeking UniversityBeijing 100191China Key Laboratory for Neuroscience of Ministry of EducationPeking UniversityBeijing 100191China Key Laboratory for Neuroscience of National Health CommissionPeking UniversityNO.38 Xueyuan RoadBeijing 100191China
出 版 物：《Medical Review》 (医学评论（英文）)
年 卷 期：2022年第2卷第4期
页 面：363-384页
学科分类：1002[医学-临床医学] 100201[医学-内科学(含：心血管病、血液病、呼吸系病、消化系病、内分泌与代谢病、肾病、风湿病、传染病)] 10[医学]
基 金：supported by grants from the National Natural Science Foundation of China(No.82170864.No.81471064.No.81670779,No.81870590 to R.Z) the Beijing Municipal Natural Science Foundation(No.7162097,No.H2018206641 to R.Z) the Peking University Research Foundation(No.BMU20140366 to R.Z) the National Key Research and Development Program of China(2017YFC1700402 to R.Z.)
主 题：leptin leptin cellular pathways leptin neural pathways leptin resistance
摘 要：With the prevalence of obesity and associated comorbidities,studies aimed at revealing mechanisms that regulate energy homeostasis have gained increasing *** 1994,the cloning of leptin was a milestone in metabolic *** an adipocytokine,leptin governs food intake and energy homeostasis through leptin receptors(LepR)in the *** failure of increased leptin levels to suppress feeding and elevate energy expenditure is referred to as leptin resistance,which encompasses complex pathophysiological *** the brain,LepR-expressing neurons are distributed in hypothalamus and other brain areas,and each population of the LepR-expressing neurons may mediate particular aspects of leptin *** LepR-expressing neurons,the binding of leptin to LepR initiates multiple signaling cascades including janus kinase(JAK)–signal transducers and activators of transcription(STAT)phosphatidylinositol 3-kinase(PI3K)-protein kinase B(AKT),extracellular regulated protein kinase(ERK),and AMP-activated protein kinase(AMPK)signaling,etc.,mediating leptin *** findings place leptin at the intersection of metabolic and neuroendocrine regulations,and render leptin a key target for treating obesity and associated *** review highlights the main discoveries that shaped the field of leptin for better understanding of the mechanism governing metabolic homeostasis,and guides the development of safe and effective interventions to treat obesity and associated diseases.
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