Astrocytes:the neglected stars in the central nervous system and drug addiction
作者机构：National Institute on Drug Dependence and Beijing Key Laboratory of Drug DependencePeking UniversityBeijing 100191China The State Key Laboratory of Natural and Biomimetic DrugsPeking UniversityBeijing 100191China The Key Laboratory for Neuroscience of the Ministry of Education and HealthPeking UniversityBeijing 100191China
出 版 物：《Medical Review》 (医学评论（英文）)
年 卷 期：2022年第2卷第4期
页 面：417-426页
基 金：funded by the Ministry of Science and Technology of China(2021ZD0202100,2021ZD0201900) National Natural Science Foundation of China(U1802283,82130040,81901352) Beijing Municipal Science&Technology Commission(Z181100001518005).
主 题：astrocytes central nervous system drug addiction synaptic plasticity
摘 要：With the advent of improved tools to examine the astrocytes,which have been believed to play a supportive role in the central nervous system(CNS)for years,their participation in the operation of the CNS and drug addiction was unveiled.Assisting the formation and function of the CNS,astrocytes are involved in physiological and pathological brain activities.Drug addiction is a pervasive psychiatric disorder,characterized by compulsive drug-taking behavior and high rate of relapse,impacting individual health and society stability and safety.When exposed to drugs of abuse,astrocytes go through a series of alterations,contributing to the development of addiction.Here we review how astrocytes contribute to the CNS and drug addiction.We hope that understanding the interaction between addictive drugs and astrocytes may help discover new mechanisms underlying the addiction and produce novel therapeutic treatments.
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