Biological factors controlling starch digestibility in human digestive system

作     者：Cheng Li Yiming Hu Songnan Li Xueer Yi Shuaibo Shao Wenwen Yu Enpeng Li Cheng Li;Yiming Hu;Songnan Li;Xueer Yi;Shuaibo Shao;Wenwen Yu;Enpeng Li

作者机构：School of Health Science and EngineeringUniversity of Shanghai for Science and TechnologyShanghai 200093China Joint International Research Laboratory of Agriculture and Agri-Product Safetythe Ministry of Education of ChinaInstitutes of Agricultural Science and Technology Development of Yangzhou UniversityYangzhou 225009China Department of PathologyZhongshan HospitalFudan UniversityShanghai 200031China Department of Food Science&EngineeringJinan UniversityGuangzhou 510632China Jiangsu Key Laboratory of Crop Genetics and Physiology/State Key Laboratory of Hybrid RiceCollege of AgricultureYangzhou UniversityYangzhou 225009China 

出 版 物：《Food Science and Human Wellness》 (食品科学与人类健康（英文）)

年 卷 期：2023年第12卷第2期

页      面：351-358页

核心收录：

学科分类：0832[工学-食品科学与工程（可授工学、农学学位）] 1004[医学-公共卫生与预防医学(可授医学、理学学位)] 1002[医学-临床医学] 10[医学] 

基　　金：financial support from National Natural Science Foundation of China(32001646) Natural Science Foundation of Jiangsu Province(BK20190906) Jiangsu Yangzhou Key Research and Development Program(SSF2018000008) Jiangsu Provincial Entrepreneurial and Innovation Phd Program Yangzhou Lvyangjinfeng Talent Program。 

主　　题：Starch digestion Human gastrointestinal tract Biological factors Gastric emptying rate Gut microbiota 

摘      要：Starch digestion rate and location in the gastrointestinal tract(GIT)are critical for human health.This review aims to present a comprehensive summary on our current understanding of physiological,biochemical,anatomical and geometrical factors of human digestive system that are related to in vivo starch digestibility.It is shown that all digestive compartments including mouth,stomach,small intestine,and large intestine play critical roles in regulating the overall starch digestion process.A proper investigation of starch digestion pattern should thus be based on the consideration of all these compartments.Main biological factors are summarized as oral mastication and salivation,gastric emptying and motility,small intestinal enzymes and motility,large intestinal resistant starch(RS)-microbiota interactions and gut-brain feedback control,as well as glucose adsorption and hormonal feedback control.However,connections among these biological factors in determining starch digestive behaviors remain elusive.This is due to the inherent complexity of human GIT anatomy,motility and biochemical conditions,as well as ethical,financial and technical issues in conducting clinical studies.Much technological and scientific efforts from both clinical studies and in vitro simulation models are required for a better understanding of in vivo starch digestion behaviors.