Au-catalyzed neighboring hydroxymethyl group directed cycloaddition of alkyne with diazadienes:Synthesis of polysubstituted pyrroles

作     者：Zhenwei Shi Wenxiu Mao Zhenning Yang Shuzhe Sun Chen-Ho Tung Zhenghu Xu Zhenwei Shi;Wenxiu Mao;Zhenning Yang;Shuzhe Sun;Chen-Ho Tung;Zhenghu Xu

作者机构：School of Chemistry and Chemical EngineeringShandong UniversityJi’nan 250100China Key Laboratory of Precise Synthesis of Functional Molecules of Zhejiang ProvinceSchool of ScienceWestlake UniversityHangzhou 310024China 

出 版 物：《Chinese Chemical Letters》 (中国化学快报（英文版）)

年 卷 期：2023年第34卷第1期

页      面：342-346页

核心收录：

学科分类：081704[工学-应用化学] 07[理学] 08[工学] 0817[工学-化学工程与技术] 070303[理学-有机化学] 0703[理学-化学] 

基　　金：the financial support from the Natural Science Foundation of China and Shandong Province(Nos.21971149,92156007,ZR2019ZD45,ZR2020KB005) the Fundamental Research Funds of Shandong University 

主　　题：Pyrrole Au Neighboring group Cascade reaction Synthetic method 

摘      要：Polysubstituted pyrroles are very important scaffolds in many bioactive natural products and synthetic ***,a new gold-catalyzed cycloaddition of alkynes with azadienes to access tetrasubstituted pyrroles is *** neighboring hydroxylmethyl group serves a very important directing group through an addition/cycloaddition/elimination *** polysubstituted pyrroles were synthesized in good yields under mild conditions in one step,and tricyclic pyrrole containing heterocycles were easily obtained through derivatization.