Towards a shape-performance integrated digital twin for lumbar spine analysis[version 1;peer review:1 approved,1 not approved]

作     者：Xiwang He Yiming Qiu Xiaonan Lai Zhonghai Li Liming Shu Wei Sun Xueguan Song 

作者机构：School of Mechanical EngineeringDalian University of TechnologyDalianLiaoning116024China Department of OrthopedicsThe First Affiliated Hospital of Dalian Medical UniversityDalianLiaoning116011China Department of Mechanical EngineeringUniversity of TokyoTokyo113-8654Japan 

出 版 物：《Digital Twin》 (数字孪生（英文）)

年 卷 期：2021年第1卷第1期

页      面：88-104页

学科分类：1002[医学-临床医学] 100210[医学-外科学(含：普外、骨外、泌尿外、胸心外、神外、整形、烧伤、野战外)] 10[医学] 

基　　金：This work was supported by the National Key R&D Program of China[2018YFC0808205] the National Natural Science Foundation of China 

主　　题：Shape-performance integrated digital twin Multiple models Dynamic data Artificial intelligence Lumbar spine 

摘      要：Background:With significant advancement and demand for digital transformation,the digital twin has been gaining increasing attention as it is capable of establishing real-time mapping between physical space and virtual *** this work,a shape-performance integrated digital twin solution is presented to predict the real-time biomechanics of the lumbar spine during human ***:A finite element model(FEM)of the lumbar spine was firstly developed using computed tomography(CT)and constrained by the body movement which was calculated by the inverse kinematics *** Gaussian process regression was utilized to train the predicted results and create the digital twin of the lumbar spine in ***,a three-dimensional virtual reality system was developed using Unity3D to display and record the real-time biomechanics performance of the lumbar spine during body ***:The evaluation results presented an agreement(R-squared0.8)between the real-time prediction from digital twin and offline FEM ***:This approach provides an effective method of real-time planning and warning in spine rehabilitation.